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foxa2xenopus   

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Experiment details for foxa2

Suzuki M et al. (2010) Assay

MID1 and MID2 are required for Xenopus neural tube closure through the regulation of microtubule organization.

Gene Clone Species Stages Anatomy
foxa2.L laevis NF stage 15 to NF stage 16 neuroectoderm , floor plate , neural tube

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  Fig. S3. In situ hybridization analysis of xMID morphants. (A-Z) Dorsal views of unilaterally injected morphants at stage 14-15; anterior is to the top. Morpholinos were injected into the right dorsal blastomere at the four-cell stage. Sox2 (A,B), NCAM (C,D) and N-cadherin (E,F) are pan-neural markers. Epidermal keratin (G,H) is an epidermal marker. HNF3β (FoxA2a) (I,J) and Pintallavis (FoxA4a) (K,L) are floor-plate markers. N-tubulin (M,N) is a marker for differentiated neurons. Shroom3 (O,P) is the essential regulator of apical constriction. Pax3 (Q,R) is a dorsal neural marker. Sonic hedgehog (Shh) (S,T), a key molecule for neural dorsoventral patterning, is expressed in the floor plate. Ptc2 (U,V) and Gli1 (W,X) are downstream targets in the Shh pathway. Gli3 (Y,Z) is a transcription factor mediating the Shh pathway. The expression patterns of all the markers in the xMID morphants were similar to those in control-Mo-injected embryos, except that the expression domains were wider than in the controls at given stages because of the delayed neural tube closure.

Gene Clone Species Stages Anatomy
foxa2.L laevis NF stage 15 neuroectoderm , neural crest , neural plate , floor plate

  foxA2 (forkhead box A2) gene expression in Xenopus laevis embryo, via in situ hybridization, NF stage 17, dorsal view, anterior up.