|
Gene |
Clone |
Species |
Stages |
Anatomy |
fgfr1
|
tneu076b03
|
tropicalis
|
NF stage 10.5
|
ectoderm
,
mesoderm
,
marginal zone
|
fgfr1
|
tneu076b03
|
tropicalis
|
NF stage 15
|
neural plate
,
anterior neural fold
,
neural plate border
|
fgfr1
|
tneu076b03
|
tropicalis
|
NF stage 23
|
presomitic mesoderm
,
pronephric duct
,
eye
,
cranial neural crest
,
pronephric kidney
|
fgfr1
|
tneu076b03
|
tropicalis
|
NF stage 28
|
otic vesicle
,
forebrain
,
hindbrain
,
presomitic mesoderm
,
somite
,
[+]
|
fgfr1
|
tneu076b03
|
tropicalis
|
NF stage 35 and 36
|
hindbrain
,
presomitic mesoderm
,
pronephric duct
,
pharyngeal arch
,
mandibular arch
,
[+]
|
fgfr1
|
tneu076b03
|
tropicalis
|
NF stage 40
|
otic vesicle
,
forebrain
,
hindbrain
,
epidermis
,
head mesoderm
,
[+]
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
fgfr2
|
|
tropicalis
|
NF stage 10.5
|
ectoderm
,
mesoderm
|
fgfr2
|
|
tropicalis
|
NF stage 15
|
neural groove
,
neural plate
,
neural plate border
|
fgfr2
|
|
tropicalis
|
NF stage 23
|
eye
,
epithelium
,
neurogenic placode
|
fgfr2
|
|
tropicalis
|
NF stage 28
|
otic vesicle
,
hindbrain
,
head mesoderm
,
notochord
,
pharyngeal arch
,
[+]
|
fgfr2
|
|
tropicalis
|
NF stage 35 and 36
to
NF stage 40
|
otic vesicle
,
head mesoderm
,
eye
,
epithelium
,
posterior
,
[+]
|
fgfr3
|
|
tropicalis
|
NF stage 10.5
|
|
fgfr3
|
|
tropicalis
|
NF stage 15
|
neural plate
|
fgfr3
|
|
tropicalis
|
NF stage 23
|
epidermis
,
eye
,
anterior neural tube
,
neurogenic placode
|
fgfr3
|
|
tropicalis
|
NF stage 28
|
forebrain
,
midbrain
,
hindbrain
,
notochord
,
eye
,
[+]
|
fgfr3
|
|
tropicalis
|
NF stage 35 and 36
|
lens
,
hindbrain
,
epidermis
,
notochord
,
mandibular arch
,
[+]
|
fgfr3
|
|
tropicalis
|
NF stage 40
|
lens
,
midbrain
,
hindbrain
,
epidermis
,
mandibular arch
,
[+]
|
fgfr4
|
|
tropicalis
|
NF stage 10.5
|
ectoderm
,
animal hemisphere
|
fgfr4
|
|
tropicalis
|
NF stage 15
|
neural plate
,
anterior neural fold
|
fgfr4
|
|
tropicalis
|
NF stage 23
|
hindbrain
,
intermediate mesoderm
,
eye
,
neural tube
,
head mesenchyme
,
[+]
|
fgfr4
|
|
tropicalis
|
NF stage 28
|
otic vesicle
,
lens
,
midbrain
,
hindbrain
,
epidermis
,
[+]
|
fgfr4
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
midbrain
,
hindbrain
,
somite
,
mandibular arch
,
[+]
|
fgfr4
|
|
tropicalis
|
NF stage 40
|
otic vesicle
,
lens
,
hindbrain
,
head mesoderm
,
somite
,
[+]
|
|
|
Figure 8. Spatial expression of the fgfr genes during early Xenopus tropicalis development. Antisense probes specific for each receptor were generated from the constructs indicated in Supp. Table 2 and in situ hybridisations were performed. 10.5a shows animal views and 10.5v shows vegetal views of gastrulating embryos, and stage15 presents dorsal views of a neurulating embryo. Stage 23, 28, 35, 40 are lateral views with anterior left and dorsal up. A schematic representation of a Xenopus embryo at stage 28 with the different embryonic tissues labelled is presented in Supp. Figure S3. |
|
Display additional annotations [+]
|
|
Figure 9. Cross-section analysis of the spatial expression patterns of the fgfrs. Coronal sections of indicated fgfrs from the whole mount in situ hybridisation shown in Figure 8. The black lines indicate the position of the sections shown. The sections labelled ldquo 1 rdquo are all at the level of the eye; the sections labelled ldquo 2 rdquo are through the otic vesicle; the sections labelled ldquo 3 rdquo are at the level of the pronephros; and the sections labelled ldquo 4 rdquo are in the tail of the embryo. In all sections, dorsal is up and ventral is down. |
|
Display additional annotations [+]
|
|
Figure 10. Detail analysis of the expression of the different fgf and fgfr genes in the otic vesicle. A Coronal sections (dorsal up) of whole mount in situ hybridisations staining within the otic vesicle for fgf1, fgf2, fgf3, fgf4, fgf8, fgf10 and fgf20 at stages 28, 35 and 40. B Coronal sections (dorsal up) of whole mount in situ hybridisations staining within the otic vesicle for fgfr1, fgfr2, fgfr3 and fgfr4 at stages 28, 35 and 40.
|