|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
fgf10
|
|
tropicalis
|
NF stage 23
|
otic placode
|
fgf10
|
|
tropicalis
|
NF stage 28
|
olfactory placode
,
otic vesicle
|
fgf10
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
forebrain
,
stomodeal-hypophyseal primordium
,
pharyngeal arch
,
optic vesicle
|
fgf10
|
|
tropicalis
|
NF stage 40
|
otic vesicle
,
head region
,
pharyngeal arch
|
fgf20
|
|
tropicalis
|
NF stage 10.5
|
mesoderm
,
marginal zone
|
fgf20
|
|
tropicalis
|
NF stage 15
|
mesoderm
|
fgf20
|
|
tropicalis
|
NF stage 23
to
NF stage 35 and 36
|
otic vesicle
,
forebrain
,
mandibular crest
,
hyoid crest
,
branchial crest
,
[+]
stomodeal-hypophyseal primordium
,
head region
,
mesoderm
,
notochord
,
branchial arch
,
tail bud
,
chordoneural hinge
,
eye
,
cranial neural crest
,
neural tube
,
tail tip
|
fgf22
|
|
tropicalis
|
NF stage 10.5
|
mesoderm
,
marginal zone
|
fgf22
|
|
tropicalis
|
NF stage 23
to
NF stage 28
|
forebrain
,
hindbrain
,
presomitic mesoderm
,
somite
,
branchial arch
,
[+]
|
fgf22
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
midbrain
,
branchial arch
,
cranial neural crest
|
fgf22
|
|
tropicalis
|
NF stage 40
|
head region
,
optic vesicle
|
fgf20
|
|
tropicalis
|
NF stage 40
|
otic vesicle
,
lens
,
head region
,
mandibular arch
,
hyoid arch
,
[+]
|
fgf9
|
|
tropicalis
|
NF stage 23
to
NF stage 40
|
presomitic mesoderm
,
somite
,
branchial arch
,
otic placode
,
eye primordium
,
[+]
|
fgf7
|
|
tropicalis
|
NF stage 23
|
branchial arch
,
optic vesicle
,
cranial neural crest
|
fgf7
|
|
tropicalis
|
NF stage 28
|
neuroectoderm
,
branchial arch
,
optic vesicle
,
dorsal tail fin
,
cranial neural crest
,
[+]
|
fgf7
|
|
tropicalis
|
NF stage 35 and 36
to
NF stage 40
|
head region
,
branchial arch
,
optic vesicle
,
cranial neural crest
,
pronephric kidney
,
[+]
|
fgf3
|
|
tropicalis
|
NF stage 15
|
circumblastoporal collar
,
neural plate
,
presumptive rhombomere
|
fgf3
|
|
tropicalis
|
NF stage 23
|
otic vesicle
,
midbrain-hindbrain boundary
,
ventricular zone
,
neuroectoderm
,
branchial arch
,
[+]
|
fgf3
|
|
tropicalis
|
NF stage 10.5
|
ectoderm
,
mesoderm
,
marginal zone
|
fgf3
|
|
tropicalis
|
NF stage 28
to
NF stage 40
|
otic vesicle
,
forebrain
,
hindbrain
,
midbrain-hindbrain boundary
,
ventricular zone
,
[+]
|
|
|
Figure 4. Analysis of the spatial expression patterns of the fgf7 and fgf9 subfamilies. A: Whole mount in situ hybridisations of fgf3, fgf7, fgf10, and fgf22 at the indicated stages. B: Whole mount in situ hybridisations of fgf9 and fgf20 at the indicated stages. For stage 10.5, the images are vegetal views; for stage 15, the images are dorsal views; and for stage 23, 28, 35, and 40, the images are lateral views (anterior is left, posterior is right, dorsal is up, and ventral is down). A schematic representation of a Xenopus embryo at stage 28 with the different embryonic tissues labelled is presented in Supp. Figure S3. |
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
fgf20
|
|
tropicalis
|
NF stage 10.5
|
mesoderm
,
marginal zone
|
fgf20
|
|
tropicalis
|
NF stage 15
|
mesoderm
|
fgf20
|
|
tropicalis
|
NF stage 23
to
NF stage 35 and 36
|
otic vesicle
,
forebrain
,
mandibular crest
,
hyoid crest
,
branchial crest
,
[+]
stomodeal-hypophyseal primordium
,
head region
,
mesoderm
,
notochord
,
branchial arch
,
tail bud
,
chordoneural hinge
,
eye
,
cranial neural crest
,
neural tube
,
tail tip
|
fgf22
|
|
tropicalis
|
NF stage 10.5
|
mesoderm
,
marginal zone
|
fgf22
|
|
tropicalis
|
NF stage 23
to
NF stage 28
|
forebrain
,
hindbrain
,
presomitic mesoderm
,
somite
,
branchial arch
,
[+]
|
fgf22
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
midbrain
,
branchial arch
,
cranial neural crest
|
fgf22
|
|
tropicalis
|
NF stage 40
|
head region
,
optic vesicle
|
fgf20
|
|
tropicalis
|
NF stage 40
|
otic vesicle
,
lens
,
head region
,
mandibular arch
,
hyoid arch
,
[+]
|
fgf9
|
|
tropicalis
|
NF stage 23
to
NF stage 40
|
presomitic mesoderm
,
somite
,
branchial arch
,
otic placode
,
eye primordium
,
[+]
|
fgf10
|
|
tropicalis
|
NF stage 10.5
|
marginal zone
|
fgf7
|
|
tropicalis
|
NF stage 23
|
branchial arch
,
optic vesicle
,
cranial neural crest
|
fgf7
|
|
tropicalis
|
NF stage 28
|
neuroectoderm
,
branchial arch
,
optic vesicle
,
dorsal tail fin
,
cranial neural crest
,
[+]
|
fgf7
|
|
tropicalis
|
NF stage 35 and 36
to
NF stage 40
|
head region
,
branchial arch
,
optic vesicle
,
cranial neural crest
,
pronephric kidney
,
[+]
|
fgf3
|
|
tropicalis
|
NF stage 15
|
circumblastoporal collar
,
neural plate
,
presumptive rhombomere
|
fgf3
|
|
tropicalis
|
NF stage 23
|
otic vesicle
,
midbrain-hindbrain boundary
,
ventricular zone
,
neuroectoderm
,
branchial arch
,
[+]
|
fgf3
|
|
tropicalis
|
NF stage 10.5
|
ectoderm
,
mesoderm
,
marginal zone
|
fgf3
|
|
tropicalis
|
NF stage 28
to
NF stage 40
|
otic vesicle
,
forebrain
,
hindbrain
,
midbrain-hindbrain boundary
,
ventricular zone
,
[+]
|
|
|
Figure 4. Analysis of the spatial expression patterns of the fgf7 and fgf9 subfamilies. A: Whole mount in situ hybridisations of fgf3, fgf7, fgf10, and fgf22 at the indicated stages. B: Whole mount in situ hybridisations of fgf9 and fgf20 at the indicated stages. For stage 10.5, the images are vegetal views; for stage 15, the images are dorsal views; and for stage 23, 28, 35, and 40, the images are lateral views (anterior is left, posterior is right, dorsal is up, and ventral is down). A schematic representation of a Xenopus embryo at stage 28 with the different embryonic tissues labelled is presented in Supp. Figure S3. |
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
fgf20
|
|
tropicalis
|
NF stage 28
to
NF stage 40
|
otic vesicle
,
stomodeal-hypophyseal primordium
,
mesoderm
,
branchial arch
,
tail bud
,
[+]
|
fgf10
|
|
tropicalis
|
NF stage 28
|
otic vesicle
|
fgf10
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
branchial arch
|
fgf7
|
|
tropicalis
|
NF stage 28
to
NF stage 40
|
branchial arch
,
mesenchyme
|
fgf3
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
midbrain-hindbrain boundary
,
branchial arch
,
tail bud
,
neural tube
|
|
|
Figure 5. Cross-section analysis of the spatial expression patterns of the fgf7 and fgf9 subfamilies. Coronal sections of the indicated fgfs from the whole mount in situ hybridisations shown in Figure 4. The black lines indicate the position of the sections shown; when multiple sections are shown numbers correspond to the appropriate black line and, therefore, the section's position on the embryo. In all sections, dorsal is up and ventral is down. |
|
|
|
fgf10 (fibroblast growth factor 10) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 23, left: lateral view, anterior left, dorsal up. right: in cross section, through otic placode, dorsal up.
|
|
Display additional annotations [+]
|
|
Figure 10. Detail analysis of the expression of the different fgf and fgfr genes in the otic vesicle. A Coronal sections (dorsal up) of whole mount in situ hybridisations staining within the otic vesicle for fgf1, fgf2, fgf3, fgf4, fgf8, fgf10 and fgf20 at stages 28, 35 and 40. B Coronal sections (dorsal up) of whole mount in situ hybridisations staining within the otic vesicle for fgfr1, fgfr2, fgfr3 and fgfr4 at stages 28, 35 and 40.
|
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
fgf10
|
|
tropicalis
|
NF stage 23
|
otic placode
|
fgf20
|
|
tropicalis
|
NF stage 28
to
NF stage 40
|
otic vesicle
,
stomodeal-hypophyseal primordium
,
mesoderm
,
branchial arch
,
tail bud
,
[+]
|
fgf7
|
|
tropicalis
|
NF stage 28
to
NF stage 40
|
branchial arch
,
mesenchyme
|
fgf3
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
midbrain-hindbrain boundary
,
branchial arch
,
tail bud
,
neural tube
|
|
|
Figure 5. Cross-section analysis of the spatial expression patterns of the fgf7 and fgf9 subfamilies. Coronal sections of the indicated fgfs from the whole mount in situ hybridisations shown in Figure 4. The black lines indicate the position of the sections shown; when multiple sections are shown numbers correspond to the appropriate black line and, therefore, the section's position on the embryo. In all sections, dorsal is up and ventral is down. |