|
Gene |
Clone |
Species |
Stages |
Anatomy |
ednra.L
|
|
laevis
|
NF stage 18
|
neural crest
,
neural plate border
|
ednra.L
|
|
laevis
|
NF stage 20
|
trunk neural crest
,
cranial neural crest
|
ednra.L
|
|
laevis
|
NF stage 26
|
otic placode
,
cranial neural crest
,
intersomitic region
,
migratory trunk neural crest cell
|
ednra.L
|
|
laevis
|
NF stage 31
|
otic vesicle
,
heart
,
trunk neural crest
,
cranial neural crest
,
intersomitic region
|
ednra.L
|
|
laevis
|
NF stage 33 and 34
|
otic vesicle
,
pronephric nephrostome
,
heart
,
cranial neural crest
|
ednra.L
|
|
laevis
|
NF stage 37 and 38
|
otic vesicle
,
pronephric nephrostome
,
heart
,
cranial neural crest
|
ednra.L
|
|
laevis
|
NF stage 40
|
fin
|
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|
|
Figure 4. Expression summary of ednrs in X. laevis.Left-lateral views in all non-prime panels save (A,B), which are dorsal (A) an anterior (B) views. All prime panels show anterior/oral views of the correspondingly lettered panel save K’, which is a dorsal view. Developmental stage69 for each specimen is indicated in the bottom right corner of a panel. (A–G) ednra expression in X. laevis. (A) ednra-a uniquely marks pre-migratory NCCs. (B–G) ednra-b expression in migratory and post-migratory NCC derivatives, nephrostomes, the heart, and fin mesenchyme. (H–J) ednrb1-a expression in X. laevis marks the eye and medial pharyngeal arch NCCs. (K–M) ednrb2-c expression in X. laevis marks migratory pigment cells, nerves, and the forebrain. All scale bars represent 100 μm, save those in (D,G,K’,L,M) which represent 500 μm. |
|
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|
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Fig. S6. Expression of edn1-3, ednra, and ednrb in X. laevis. Left lateral views in panels A, D, G, H, J, L, O, and R. Sections shown in panels B, C, E, F, I, K, M, N, P, Q, and S correspond to the labeled red line in the wholemount ISH panel for each gene. Developmental stage69 is indicated in the bottom right corner of the wholemount panel for each specimen. Note strong background staining with the edn2-a CDS probe in the brain (I). Arrows in O and P indicate ednrb2-a expression in the branchial nerves. Arrows in Q indicate expression consistent with dorsal root ganglia. Arrowheads in Q indicate expression in melanophores. Arrows in R and S indicate ednra-b expression in nephrostomes. |