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Supplementary Fig. 5. Developmental expression of adam13 and related genes. (A-E) The expression pattern of adam13 (A) overlaps with those of efnB1 (B), efnB2 (C), snail2 (D) and cerberus (cer; E) in dorsal mesoderm during early gastrulation (stage ~10.5). Embryos were cleared with 2:1 benzyl benzoate/benzyl alcohol before photographed. All embryos are shown in vegetal pole views, and arrows point to dorsal lip of blastopore. (F-H) Expression of adam13 (F), efnB1 (G) and efnB2 (H) in the presumptive eye field during early neurulation (stage 13-15). All embryos are shown in dorsal views, and brackets indicate the anterior neural plate that corresponds to the eye field. |
