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Fig. 4 – Knockdown of xkindlin2 resulted in impaired
development of the embryonic vasculature and lymphatic
system. (A–D) RNA in situ hybridization using aplnr as an
endothelial cell marker. (A–B) Initial formation and
elaboration of blood vessels including the posterior cardinal
vein (pcv) was comparable between ConMO and K2MO
morphants. (C–D) By stage 42, major vessels such as the pcv
appeared to regress in K2MO morphants. (E–F) RNA in situ
hybridizations using prox1 as a marker of the lymphatic
system showed that lymph hearts (lh) and lymph vessels
(lv) formed in both ConMO and K2MO morphants;
discontinuities in prox1 expression are noted in K2MO
embryos. |