Gene Expression Search Experiment

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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
abl2	xenopus		otic placode [+] amphibian papilla,anterior crista,auditory hair cell,auditory ossicle,auditory tube,basilar papilla,endolymphatic duct,footplate of the stapes,inner ear,lagena,lateral crista,middle ear,osseous labyrinth,otic capsule,oval window,pars externa of the stapes,pars interna of the stapes,pars media of the stapes,posterior crista,prootic bone,saccular macula,semicircular canal,stapes,tympanic annulus,tympanic disk,vestibular apparatus,vestibule,auditory apparatus,otic capsule,otic vesicle,vestibulocochlear ganglion

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Experiment details for abl2

Bonacci G et al. (2012) Assay

The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organization.

Gene	Clone	Species	Stages	Anatomy
abl2.L		laevis	NF stage 22	otic placode
abl2.L		laevis	NF stage 28	otic vesicle

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Fig. 1. Expression of Arg during early Xenopus development. A) Schematic representation of sequence alignment between human and Xenopus Arg proteins. The SH2, SH3 and tyrosine kinase domains are over 92% identical, while the actin binding domains (BDs) are 74–76% identical between the two proteins. B) Temporal expression of Arg assayed by RT-PCR (25 cycles) showed that Arg was expressed maternally and its transcripts persisted till at least tailbud stages. C) Spatial expression of Arg assayed by in situ hybridization of gastrula (panels a and b), neurula (panel c), tailbud (panels d and e) and early tadpole (panel f) embryos. The orientations of the embryos are: panel a, side view with dorsal to the right; panel b, vegetal view with dorsal to the right; panels c and e, dorsal view with anterior to the left; panels d and f, side view with anterior to the left.

Gene	Clone	Species	Stages	Anatomy
abl2.L		laevis	NF stage 22	otic placode

abl2 (ABL proto-oncogene 2) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 22, lateral view, anterior left, dorsal up.

Gene	Clone	Species	Stages	Anatomy
abl2.L		laevis	NF stage 28	otic vesicle

abl2 (ABL proto-oncogene 2) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 11, lateral view, anterior left, dorsal up.