The usp16 gene in Xenopus laevis and Xenopus tropicalis encodes a deubiquitinating enzyme that functions in histone H2A deubiquitination, influencing chromatin remodeling and gene expression during emb...[+]

The usp16 gene in Xenopus laevis and Xenopus tropicalis encodes a deubiquitinating enzyme that functions in histone H2A deubiquitination, influencing chromatin remodeling and gene expression during embryonic development. It localizes to the nucleus and is involved in cell cycle regulation, neural crest formation, and embryonic patterning. The protein acts as a ubiquitin-specific protease, contributing to transcriptional regulation and developmental processes. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD