The chd4 gene encodes a chromodomain helicase DNA-binding protein 4, which functions as an atp-dependent chromatin remodeling factor and a transcriptional corepressor. It is a subunit of the nucleosome...[+]

The chd4 gene encodes a chromodomain helicase DNA-binding protein 4, which functions as an atp-dependent chromatin remodeling factor and a transcriptional corepressor. It is a subunit of the nucleosome remodeling and deacetylase complex, localizing to the nucleus. This protein regulates gene expression during early embryonic development, including processes like neural crest formation and tailbud morphogenesis. It interacts with histone deacetylases to modify chromatin structure and repress transcription. [-]

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