Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the in...[+]

Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. [-]

             restrictive dermopathy
             Charcot-Marie-Tooth disease type 2B1
             obsolete autosomal dominant limb-girdle muscular dystrophy type 1B
             dilated cardiomyopathy 1A
             congenital muscular dystrophy due to LMNA mutation
             Emery-Dreifuss muscular dystrophy
             progeria
             Werner syndrome
             dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome
             familial partial lipodystrophy type 2
             mandibuloacral dysplasia type A lipodystrophy
             restrictive dermopathy 1
             autosomal recessive Emery-Dreifuss muscular dystrophy 3
             autosomal dominant Emery-Dreifuss muscular dystrophy 2

          LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2; FPLD2
          CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2B1; CMT2B1
          EMERY-DREIFUSS MUSCULAR DYSTROPHY 2, AUTOSOMAL DOMINANT; EDMD2
          HUTCHINSON-GILFORD PROGERIA SYNDROME; HGPS
          MANDIBULOACRAL DYSPLASIA WITH TYPE A LIPODYSTROPHY; MADA
          RESTRICTIVE DERMOPATHY 1; RSDM1
          WERNER SYNDROME; WRN
          MUSCULAR DYSTROPHY, CONGENITAL, LMNA-RELATED
          CARDIOMYOPATHY, DILATED, WITH HYPERGONADOTROPIC HYPOGONADISM
          EMERY-DREIFUSS MUSCULAR DYSTROPHY 3, AUTOSOMAL RECESSIVE; EDMD3
          HEART-HAND SYNDROME, SLOVENIAN TYPE

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