The sp6 protein is a transcription factor of the SP/KLF family containing three c2h2-type zinc fingers. It binds to specific promoter elements such as the gtg box via its dna-binding domain to regulate...[+]

The sp6 protein is a transcription factor of the SP/KLF family containing three c2h2-type zinc fingers. It binds to specific promoter elements such as the gtg box via its dna-binding domain to regulate transcription. The mrna is expressed in the cement gland, pronephros, brain, branchial arches, and olfactory placodes during development. Its function involves roles in epidermis formation and it operates within a gene regulatory network downstream of bmp and fgf signaling for ectodermal patterning. [-]

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