The uhrf1 gene encodes a nuclear protein that functions as a transcriptional regulator involved in DNA methylation and epigenetic regulation. In Xenopus laevis and Xenopus tropicalis, the uhrf1 protein...[+]

The uhrf1 gene encodes a nuclear protein that functions as a transcriptional regulator involved in DNA methylation and epigenetic regulation. In Xenopus laevis and Xenopus tropicalis, the uhrf1 protein localizes to the nucleus and is involved in chromatin remodeling, DNA methylation maintenance, and cell cycle regulation. It plays a critical role in embryonic development, including neural development and organogenesis, with expression observed in the neural tube, somites, and other developing tissues. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD