The ilf3 gene encodes an interleukin enhancer-binding factor 3, a double-stranded RNA-binding protein and transcription factor that localizes to the nucleus. It regulates histone mRNA processing and is...[+]

The ilf3 gene encodes an interleukin enhancer-binding factor 3, a double-stranded RNA-binding protein and transcription factor that localizes to the nucleus. It regulates histone mRNA processing and is involved in neurodevelopment, with expression observed in the brain, neural crest, spinal cord, and branchial arches during embryogenesis. The protein functions in the biogenesis of replication-dependent histone mRNAs, binding to the stem-loop structure in their 3' UTRs. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD