The efna5 gene encodes an ephrin-A protein which is a gpi-anchored cell surface signaling ligand that binds to eph receptors. It is involved in axon guidance and the establishment of topographic maps i...[+]

The efna5 gene encodes an ephrin-A protein which is a gpi-anchored cell surface signaling ligand that binds to eph receptors. It is involved in axon guidance and the establishment of topographic maps in the visual system, specifically in the patterning of the retinotectal projection. Expression is found in the optic tectum and the retina. The protein functions as a repulsive cue for temporal retinal ganglion cell axons, contributing to the ordered wiring from the retina to the tectum. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD