The wnt6 gene in Xenopus laevis and Xenopus tropicalis encodes a secreted signaling protein that functions as a ligand in the Wnt signaling pathway. The protein is involved in embryonic development, in...[+]

The wnt6 gene in Xenopus laevis and Xenopus tropicalis encodes a secreted signaling protein that functions as a ligand in the Wnt signaling pathway. The protein is involved in embryonic development, including roles in neural crest formation, myogenesis, and craniofacial development. It acts through the canonical Wnt/β-catenin signaling pathway. The protein is secreted and functions in a paracrine manner to regulate cell fate decisions during embryogenesis. Expression is observed in the developing nervous system, somites, and craniofacial structures. The protein contains a Wnt1 domain and is lipid-modified for secretion. Its activity is regulated by extracellular inhibitors such as Dkk1 and Sfrps. The protein's function is essential for proper patterning of the neural tube, somites, and craniofacial structures. [-]

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