The wnt4 gene encodes a secreted signaling protein that functions as a ligand in the Wnt signaling pathway. It acts as a short-range signaling molecule during embryonic development. The wnt4 protein is...[+]

The wnt4 gene encodes a secreted signaling protein that functions as a ligand in the Wnt signaling pathway. It acts as a short-range signaling molecule during embryonic development. The wnt4 protein is involved in regulating cell fate determination and tissue morphogenesis. It plays a role in the development of the pronephros and is necessary for the formation of the Müllerian ducts. The protein is secreted and acts through the canonical Wnt/β-catenin signaling pathway. It is expressed in specific tissues including the developing kidney and reproductive tracts. The protein functions as a paracrine factor to coordinate cell proliferation and differentiation. Its activity is essential for the proper formation of the excretory and reproductive systems. The protein's function is critical for the development of the mesonephric tubules and the Müllerian ducts. It also plays a role in the development of the adrenal gland and the gonads. The protein acts as a morphogen to pattern the developing embryo. It is required for the specification of cell types in the kidney and reproductive tracts. The protein's activity is regulated by extracellular inhibitors and activators. It functions in a concentration-dependent manner to specify cell fates. The protein is modified by glycosylation and palmitoylation, which are essential for its secretion and activity. The protein forms a gradient that patterns the developing embryo. It signals through the Frizzled family of receptors and activates the canonical Wnt signaling pathway. The protein's activity is modulated by extracellular antagonists such as Dickkopf and secreted Frizzled-related proteins. The protein's expression is dynamically regulated during embryogenesis. It is required for the development of the mesonephric tubules and the Müllerian ducts. The protein's function is conserved across Xenopus laevis and Xenopus tropicalis. The gene is expressed in a dynamic pattern during embryogenesis. The protein's function is essential for the development of the excretory and reproductive systems. It is required for the formation of the mesonephros and the Müllerian ducts. The protein acts as a key regulator of cell fate decisions during embryogenesis. [-]

             Mullerian aplasia and hyperandrogenism
             Mayer-Rokitansky-Kuster-Hauser syndrome type 1

          MULLERIAN APLASIA AND HYPERANDROGENISM
          46,XX SEX REVERSAL WITH DYSGENESIS OF KIDNEYS, ADRENALS, AND LUNGS; SERKAL

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD