The frg1 gene encodes an f-box only protein that functions as a component of the scf e3 ubiquitin-protein ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of targe...[+]

The frg1 gene encodes an f-box only protein that functions as a component of the scf e3 ubiquitin-protein ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of target proteins. this protein is localized to the nucleus. it is expressed in the developing eye, brain, branchial arches, otic vesicle, and pronephros during embryogenesis. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD