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Summary Expression Phenotypes Gene Literature (1) GO Terms (8) Nucleotides (211) Proteins (56) Interactants (75) Wiki
XB-GENEPAGE-950143
Gene Symbol:
 erlin2

Gene Name: 
ER lipid raft associated 2

Synonyms:
erlin2-a , erlin2-b , spfh2 ( Nomenclature history )

Gene Function:
Prohibitin-related membrane protease subunits

Protein Function :
Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Promotes sterol-accelerated ERAD of HMGCR. Involved in regulation of cellular cholest...[+]


InterPro :
Band 7, Erlin1/2, DPH6/MJ0570, Diphthami syn dom, [+]

Interactants:
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Diseases: 


Disease Ontology:
hereditary spastic paraplegia 18

OMIM:
SPASTIC PARAPLEGIA 18, AUTOSOMAL RECESSIVE; SPG18

External Links:
 
Expression                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info