mapt Phenotypes

Summary

Expression

Phenotypes

Gene Literature (202)

XB-GENEPAGE-986947

Gene Symbol: mapt Gene Name: microtubule associated protein tau

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased alpha-tubulin acetylation (2 sources), abnormal axon microtubule bundle morphology (1 source), abnormal development of peripheral nerve (1 source), abnormal growth cone morphology (1 source), abnormal microtubule morphology (1 source), abnormal neuron projection morphology (1 source), abnormally increased number of neuron (1 source), decreased length of facial nerve (1 source), decreased length of glossopharyngeal nerve (1 source), decreased length of spinal nerve (1 source), decreased length of trigeminal nerve (1 source), decreased length of vagus nerve (1 source), decreased size of the axon microtubule bundle (1 source), decreased size of the microtubule (1 source), increased size of the neuron projection (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

increased alpha-tubulin acetylation (2 sources), abnormal axon microtubule bundle morphology (1 source), abnormal development of peripheral nerve (1 source), abnormal growth cone morphology (1 source), abnormal microtubule morphology (1 source), abnormal neuron projection morphology (1 source), abnormally increased number of neuron (1 source), decreased length of facial nerve (1 source), decreased length of glossopharyngeal nerve (1 source), decreased length of spinal nerve (1 source), decreased length of trigeminal nerve (1 source), decreased length of vagus nerve (1 source), decreased size of the axon microtubule bundle (1 source), decreased size of the microtubule (1 source), increased size of the neuron projection (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: mapt manipulated (2 sources)
Computed annotations: mapt assayed (4 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + Mapt MO (3 sources), Xla Wt + Mapt MO + neural tube explant (2 sources), Xla Wt + mapt1 + neural tube explant (2 sources), Xla Wt + mapt2 + neural tube explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (78 sources): Abnormal pyramidal sign, Abnormal saccadic eye movements, Abnormality of eye movement, Abulia, Akinesia, Alexia, Amyotrophic lateral sclerosis, Anomic aphasia, Apathy, Aphasia, Axial dystonia, Axial muscle stiffness, Blepharospasm, Blurred vision, Bradykinesia, Brain atrophy, Conjunctival hyperemia, Decreased lacrimation, Dementia, Depression, Diminished motivation, Diplopia, Disinhibition, Dysarthria, Dysgraphia, Dyslexia, Dysphagia, Dystonia, Echolalia, Emotional blunting, Eyelid apraxia, Falls, Frontal lobe dementia, Frontal release signs, Frontolimbic dementia, Frontotemporal dementia, Gait imbalance, Gliosis, Granulovacuolar degeneration, Hyperorality, Impaired visuospatial constructive cognition, Impulsivity, Inappropriate laughter, Inappropriate sexual behavior, Irritability, Kyphoscoliosis, Language impairment, Limb dystonia, Memory impairment, Mental deterioration, Morphological abnormality of the pyramidal tract, Motor stereotypy, Mutism, Neurofibrillary tangles, Neurological speech impairment, Neuromuscular dysphagia, Neuronal loss in basal ganglia, Neuronal loss in central nervous system, Ophthalmoparesis, Parkinsonism, Parkinsonism with favorable response to dopaminergic medication, Perseveration, Personality changes, Photophobia, Polyphagia, Postural instability, Primitive reflex, Progressive extrapyramidal muscular rigidity, Respiratory distress, Retrocollis, Rigidity, Slow saccadic eye movements, Slowed slurred speech, Social and occupational deterioration, Supranuclear gaze palsy, Tremor, Vertical supranuclear gaze palsy, Visual agnosia [+]
Mouse (34 sources): abnormal axon extension, abnormal axon morphology, abnormal axonal transport, abnormal dendrite morphology, abnormal dentate gyrus morphology, abnormal dorsal root ganglion morphology, abnormal excitatory postsynaptic potential, abnormal hippocampus CA1 region morphology, abnormal hippocampus pyramidal cell morphology, abnormal long term object recognition memory, abnormal motor learning, abnormal motor neuron innervation pattern, abnormal retina blood vessel morphology, abnormal retina vasculature morphology, abnormal sensory neuron innervation pattern, abnormal sensory neuron morphology, abnormal spatial learning, abnormal spatial working memory, abnormal synaptic bouton morphology, behavior/neurological phenotype, decreased anxiety-related response, decreased grip strength, decreased muscle spindle number, decreased susceptibility to pharmacologically induced seizures, enhanced spatial learning, impaired contextual conditioning behavior, impaired cued conditioning behavior, increased anxiety-related response, increased cell proliferation, increased thigmotaxis, nervous system phenotype, no abnormal phenotype detected, persistence of hyaloid vascular system, reduced long term potentiation [+]
View all ortholog results at Monarch