abnormal visceral yolk sac morphology, abnormal vitelline vascular remodeling, abnormal vitelline vasculature morphology, absent Z line, absent atrioventricular cushions, absent heartbeat, absent placenta hemotrichorial membrane, absent placental labyrinth, absent vitelline blood vessels, cardiac interstitial fibrosis, decreased cardiac muscle contractility, decreased embryo size, decreased myocardial fiber number, dilated mitochondria, distended pericardium, embryo tissue necrosis, embryonic growth arrest, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, enlarged first pharyngeal arch, enlarged pericardium, impaired smooth muscle contractility, increased cardiomyocyte apoptosis, increased embryonic tissue cell apoptosis, increased insulin secretion, increased left ventricle diastolic pressure, increased left ventricle systolic pressure, increased pancreatic beta cell mass, increased pancreatic beta cell proliferation, increased ventricle muscle contractility, poor circulation, pregnancy-related premature death, premature death, thin ventricular wall, trabecula carnea hypoplasia