| Monarch Ortholog Phenotypes
|
Human (43 sources):
Abnormality of the digestive system,
Abnormality of the immune system,
Airway obstruction,
Asplenia,
Asthma,
Atelectasis,
Bronchiectasis,
Chronic bronchitis,
Chronic otitis media,
Chronic sinusitis,
Ciliary dyskinesia,
Clubbing of fingers,
Conductive hearing impairment,
Corneal dystrophy,
Cough,
Delayed speech and language development,
Ectopic pregnancy,
Glue ear,
Halitosis,
Headache,
Hydrocephalus,
Immotile cilia,
Impaired nasal mucociliary clearance,
Infertility,
Miscarriage,
Myopia,
Nasal polyposis,
Pectus excavatum,
Pneumonia,
Recurrent bronchitis,
Recurrent otitis media,
Recurrent respiratory infections,
Recurrent sinusitis,
Reduced sperm motility,
Respiratory distress,
Respiratory insufficiency due to defective ciliary clearance,
Respiratory tract infection,
Rhinitis,
Scoliosis,
Sinusitis,
Situs inversus totalis,
Tachypnea,
Ventriculomegaly
[+]
|
Mouse (23 sources):
abnormal aggression-related behavior,
abnormal brain ependyma motile cilium morphology,
abnormal brain ependyma motile cilium physiology,
abnormal brain meninges morphology,
abnormal cerebral aqueduct morphology,
abnormal cranium morphology,
abnormal ependyma morphology,
abnormal ependyma motile cilium morphology,
abnormal interventricular foramen morphology,
abnormal mucociliary clearance,
abnormal telencephalon morphology,
decreased body size,
decreased locomotor activity,
domed cranium,
enlarged cranium,
enlarged parietal bone,
postnatal lethality,
postnatal lethality, complete penetrance,
premature death,
small cerebellum,
small olfactory bulb,
thin cerebral cortex,
thymus atrophy
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.