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Summary Expression Phenotypes Gene Literature (78) GO Terms (11) Nucleotides (267) Proteins (47) Interactants (427) Wiki

vangl2     VANGL planar cell polarity protein 2

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal neural tube closure (4 sources), decreased length of anterior-posterior axis (3 sources), abnormally delayed closure of blastopore (2 sources), abnormal bending of dorsal trunk (1 source), abnormal cell migration (1 source), abnormal convergent extension involved in axis elongation (1 source), abnormal development of upper blastopore lip (1 source), abnormal establishment of epithelial cell planar polarity (1 source), abnormally increased number of multiciliated cell (1 source), absent blastopore (1 source), absent epidermis outer layer (1 source), absent multiciliated cell (1 source), decreased length of dorsal-ventral axis (1 source), increased thickness of the ectoderm (1 source), increased thickness of the epidermis (1 source), increased thickness of the neural plate (1 source), increased thickness of the non-neural ectoderm (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: vangl2 manipulated (7 sources), vangl2 assayed (4 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + vangl2 MO (9 sources), Xla Wt + vangl2 MO (3 sources), Xla Wt + vangl2 MO (3 sources), Xla wt + vangl2 mRNA (2 sources), Xla Wt + HA-vangl2T76>A,T78>A (1 source), Xla Wt + vangl2 (1 source), Xla Wt + vangl2 (1 source), Xla Wt + vangl2 (1 source), Xla Wt + vangl2 MO (1 source), Xla Wt + vangl2 MO + sqstm1 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (10 sources): Absence of the sacrum, Anencephaly, Asymmetry of spinal facet joints, Hydrocephalus, Lipoma, Multiple lipomas, Myelomeningocele, Sacral dimple, Spina bifida occulta, Urinary incontinence
Mouse (105 sources): aberrant origin of the right subclavian artery, abnormal Deiters cell morphology, abnormal body wall morphology, abnormal brain development, abnormal brain ventricle morphology, abnormal brain ventricular system morphology, abnormal branching involved in lung morphogenesis, abnormal cerebral hemisphere morphology, abnormal cervical flexure morphology, abnormal cochlea morphology, [+]

View all ortholog results at Monarch