| Monarch Ortholog Phenotypes
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Human (19 sources):
Absent speech,
Broad-based gait,
CNS hypomyelination,
Delayed myelination,
Feeding difficulties,
Global developmental delay,
High palate,
Hypotonia,
Intellectual disability,
Myoclonus,
[+]
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Mouse (31 sources):
abnormal DNA replication,
abnormal Purkinje cell morphology,
abnormal axon morphology,
abnormal brain white matter morphology,
abnormal bronchiole epithelium morphology,
abnormal cerebellar cortex morphology,
abnormal cerebellar granule layer morphology,
abnormal cerebellar molecular layer,
abnormal cerebellum development,
abnormal cerebellum external granule cell layer morphology,
abnormal dentate gyrus morphology,
abnormal hippocampus stratum lacunosum morphology,
abnormal nervous system tract morphology,
abnormal neuron proliferation,
abnormal neuronal precursor proliferation,
abnormal tail movements,
abnormal thymus morphology,
decreased CNS synapse formation,
decreased Purkinje cell number,
decreased cell proliferation,
decreased cerebellar granule cell number,
decreased locomotor activity,
decreased neuron number,
decreased spleen weight,
increased brain size,
increased brain weight,
postnatal lethality, incomplete penetrance,
premature death,
slow postnatal weight gain,
small spleen,
weakness
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.