Monarch Ortholog Phenotypes
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Mouse (32 sources):
abnormal AMPA-mediated synaptic currents,
abnormal CNS synapse formation,
abnormal CNS synaptic transmission,
abnormal Purkinje cell innervation,
abnormal brain wave pattern,
abnormal crista ampullaris morphology,
abnormal excitatory postsynaptic currents,
abnormal hippocampal mossy fiber morphology,
abnormal innervation,
abnormal locomotor coordination,
abnormal miniature excitatory postsynaptic currents,
abnormal neuromuscular synapse morphology,
abnormal neuron differentiation,
abnormal synapse morphology,
abnormal synaptic vesicle morphology,
abnormal synaptic vesicle number,
abnormal type I vestibular cell,
abnormal vestibular hair cell morphology,
circling,
decreased CNS synapse formation,
decreased body size,
decreased startle reflex,
decreased vertical activity,
head bobbing,
head shaking,
head tossing,
impaired righting response,
impaired swimming,
increased or absent threshold for auditory brainstem response,
loss of hippocampal neurons,
nervous system phenotype,
reduced AMPA-mediated synaptic currents
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