mc4r Phenotypes

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Phenotypes

Gene Literature (6)

Nucleotides (43)

Interactants (111)

XB-GENEPAGE-960721

Gene Symbol: mc4r Gene Name: melanocortin 4 receptor

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (11 sources): Acanthosis nigricans, Childhood-onset truncal obesity, Hyperinsulinemia, Hypertension, Hypertriglyceridemia, Increased adipose tissue, Increased bone mineral density, Obesity, Polyphagia, Tall stature, Type II diabetes mellitus [+]
Mouse (36 sources): abnormal circadian behavior phase, abnormal food intake, abnormal locomotor activation, abnormal oxygen consumption, adipose tissue inflammation, behavior/neurological phenotype, cardiovascular system phenotype, decreased circulating adiponectin level, decreased lean body mass, decreased osteoclast cell number, decreased oxygen consumption, growth/size/body region phenotype, homeostasis/metabolism phenotype, increased abdominal fat pad weight, increased body length, increased body mass index, increased body size, increased bone mass, increased circulating alanine transaminase level, increased circulating aspartate transaminase level, increased circulating interleukin-6 level, increased energy expenditure, increased food intake, increased hepatocellular carcinoma incidence, increased hydroxyproline level, increased lean body mass, increased liver triglyceride level, increased liver weight, increased percent body fat/body weight, increased susceptibility to diet-induced obesity, increased susceptibility to weight gain, increased total body fat amount, microvesicular hepatic steatosis, no abnormal phenotype detected, reduced fertility, respiratory system phenotype [+]
View all ortholog results at Monarch