pcsk2 Phenotypes

Phenotypes

XB-GENEPAGE-960012

Gene Symbol: pcsk2 Gene Name: proprotein convertase subtilisin/kexin type 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: pcsk2 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (32 sources): abnormal gland physiology, abnormal locomotor behavior, abnormal pancreatic alpha cell differentiation, abnormal pancreatic alpha cell morphology, abnormal pancreatic beta cell differentiation, abnormal pancreatic islet morphology, abnormal pancreatic somatostatin secretion, analgesia, decreased circulating glucose level, decreased glucagon secretion, decreased insulin secretion, decreased pituitary hormone level, dilated renal tubules, homeostasis/metabolism phenotype, hyporesponsive to tactile stimuli, improved glucose tolerance, increased circulating creatinine level, increased circulating iron level, increased glucagonoma incidence, increased pancreatic alpha cell mass, increased pancreatic alpha cell number, increased pancreatic alpha cell proliferation, increased pancreatic delta cell number, increased pancreatic ductal adenocarcinoma incidence, increased pancreatic islet cell adenoma incidence, increased systemic arterial blood pressure, increased thermal nociceptive threshold, limb grasping, pancreatic islet hyperplasia, premature death, preweaning lethality, incomplete penetrance, reduced female fertility [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (32 sources): abnormal gland physiology, abnormal locomotor behavior, abnormal pancreatic alpha cell differentiation, abnormal pancreatic alpha cell morphology, abnormal pancreatic beta cell differentiation, abnormal pancreatic islet morphology, abnormal pancreatic somatostatin secretion, analgesia, decreased circulating glucose level, decreased glucagon secretion, [+]