mbp Phenotypes

Phenotypes

XB-GENEPAGE-959615

Gene Symbol: mbp Gene Name: myelin basic protein

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: mbp assayed (6 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (38 sources): abnormal CNS synaptic transmission, abnormal action potential, abnormal auditory brainstem response waveform shape, abnormal axonal transport, abnormal brain white matter morphology, abnormal cerebellum white matter morphology, abnormal maternal nurturing, abnormal myelin sheath morphology, abnormal spatial learning, absent linear vestibular evoked potential, audiogenic seizures, convulsive seizures, decreased brain cholesterol level, decreased cholesterol level, decreased locomotor activity, decreased startle reflex, decreased susceptibility to Picornaviridae infection, environmentally induced seizures, hindlimb paralysis, immune system phenotype, increased T cell proliferation, increased interferon-gamma secretion, increased interleukin-2 secretion, increased interleukin-4 secretion, increased or absent threshold for auditory brainstem response, increased susceptibility to experimental autoimmune encephalomyelitis, increased susceptibility to neuronal excitotoxicity, increased susceptibility to pharmacologically induced seizures, limb grasping, paresis, phenotypic reversion, premature death, reduced linear vestibular evoked potential, reproductive system phenotype, reversion by mitotic recombination, sporadic seizures, tonic seizures, vision/eye phenotype [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (38 sources): abnormal CNS synaptic transmission, abnormal action potential, abnormal auditory brainstem response waveform shape, abnormal axonal transport, abnormal brain white matter morphology, abnormal cerebellum white matter morphology, abnormal maternal nurturing, abnormal myelin sheath morphology, abnormal spatial learning, absent linear vestibular evoked potential, [+]