Bulbar palsy, Cerebral cortical atrophy, Degeneration of the lateral corticospinal tracts, Depression, Disinhibition, Distal muscle weakness, Dysarthria, Dyscalculia, Dysphagia, Fasciculations, Frontotemporal dementia, Generalized amyotrophy, Gliosis, Global brain atrophy, Hallucinations, Hyperreflexia, Hyporeflexia, Language impairment, Muscle weakness, Mutism, Neuronal loss in the cerebral cortex, Paraparesis, Parkinsonism, Perseverative thought, Personality changes, Progressive cerebellar ataxia, Proximal muscle weakness, Ptosis, Skeletal muscle atrophy, Supranuclear gaze palsy, Tetraparesis, Weakness due to upper motor neuron dysfunction

increased anti-nuclear antigen antibody level, increased circulating creatinine level, increased circulating interleukin-10 level, increased circulating interleukin-1 beta level, increased circulating interleukin-6 level, increased circulating tumor necrosis factor level, increased interleukin-6 secretion, increased mature B cell number, increased NK T cell number, increased spleen weight, increased susceptibility to bacterial infection induced morbidity/mortality, increased susceptibility to endotoxin shock, increased tumor necrosis factor secretion, lethality throughout fetal growth and development, complete penetrance, liver hemorrhage, lymphoid hyperplasia, postnatal lethality, complete penetrance, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, skin edema, skin hyperplasia