| Monarch Ortholog Phenotypes
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Human (14 sources):
Abnormality of the skeletal system,
Agenesis of corpus callosum,
Behavioral abnormality,
Global developmental delay,
Gray matter heterotopia,
Hydrocephalus,
Intellectual disability, severe,
Macrocephaly,
Polymicrogyria,
Seizure,
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Mouse (38 sources):
abnormal brain development,
abnormal cerebral cortex morphology,
abnormal cortical intermediate zone morphology,
abnormal cortical plate morphology,
abnormal cortical ventricular zone morphology,
abnormal cranium morphology,
abnormal dorsal subiculum morphology,
abnormal embryonic/fetal subventricular zone morphology,
abnormal hippocampus CA3 region morphology,
abnormal hippocampus pyramidal cell layer,
abnormal locomotor activation,
abnormal locomotor behavior,
abnormal mitotic spindle morphology,
abnormal neuronal precursor proliferation,
abnormal radial glial cell morphology,
abnormal righting response,
absent pinna reflex,
decreased anterior commissure size,
decreased body size,
decreased cingulate cortex size,
decreased erythrocyte cell number,
decreased fasting circulating glucose level,
decreased locomotor activity,
delayed eyelid opening,
delayed hair appearance,
ectopic cortical neuron,
ectopic neuron,
enlarged lateral ventricles,
impaired spatial learning,
increased mean corpuscular hemoglobin,
increased neuron apoptosis,
increased susceptibility to pharmacologically induced seizures,
nervous system phenotype,
premature death,
preweaning lethality, incomplete penetrance,
round head,
small lateral ventricles,
thin cerebral cortex
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.