| Monarch Ortholog Phenotypes
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Human (18 sources):
Abnormal circulating hormone concentration,
Acanthosis nigricans,
Calf muscle hypertrophy,
Diabetes mellitus,
Hepatic fibrosis,
Hepatic steatosis,
Hyperinsulinemia,
Hypertension,
Hypertriglyceridemia,
Infertility,
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Mouse (33 sources):
abnormal adipose tissue physiology,
abnormal blood homeostasis,
abnormal brown adipose tissue morphology,
abnormal brown adipose tissue physiology,
abnormal circulating free fatty acids level,
abnormal circulating ketone body level,
abnormal fat pad morphology,
abnormal glycerol level,
abnormal lipolysis,
abnormal white adipose tissue mass,
adipose tissue phenotype,
decreased brown adipose tissue amount,
decreased brown fat cell lipid droplet size,
decreased brown fat lipid droplet number,
decreased epididymal fat pad weight,
decreased inguinal fat pad weight,
decreased interscapular fat pad weight,
decreased parametrial fat pad weight,
decreased percent body fat/body weight,
decreased retroperitoneal fat pad weight,
decreased susceptibility to diet-induced obesity,
decreased total fat pad weight,
decreased white adipose tissue mass,
decreased white fat cell size,
enhanced lipolysis,
growth/size/body region phenotype,
homeostasis/metabolism phenotype,
impaired adaptive thermogenesis,
impaired lipolysis,
increased food intake,
increased gastrocnemius weight,
increased lean body mass,
increased oxygen consumption
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.