abnormal locomotor activation, abnormal palate development, abnormal periderm development, abnormal stomach epithelium morphology, abnormal vertebral spinous process morphology, absent vertebral arch, curly tail, decreased blood urea nitrogen level, decreased circulating alkaline phosphatase level, decreased embryo size, delayed neural tube closure, epidermal hyperplasia, excessive scratching, eyelids open at birth, fetal growth retardation, impaired skin barrier function, increased circulating glucose level, increased incidence of tumors by chemical induction, increased keratinocyte proliferation, increased skin papilloma incidence, increased tumor incidence, integument phenotype, intestinal hemorrhage, kinked tail, lethality during fetal growth through weaning, complete penetrance, nervous system phenotype, no abnormal phenotype detected, open neural tube, perinatal lethality, complete penetrance, preweaning lethality, complete penetrance, skin lesions, spina bifida cystica, thick epidermis stratum spinosum