abnormal granulocyte differentiation, abnormal gut flora balance, abnormal immune system organ morphology, abnormal lymph node cortex morphology, abnormal lymph node medulla morphology, abnormal lymphopoiesis, abnormal macrophage differentiation, abnormal myelopoiesis, abnormal natural killer cell mediated cytotoxicity, abnormal peripheral lymph node morphology, abnormal splenic cell ratio, abnormal thymocyte activation, abnormal thymus cortex morphology, abnormal thymus development, abnormal thymus lobule morphology, abnormal thymus medulla morphology, abnormal thymus morphology, absent B-1a cells, absent Peyer's patches, absent T cells, absent axillary lymph nodes, absent cervical lymph nodes, absent inguinal lymph nodes, absent mesenteric lymph nodes, absent pre-B cells, absent pro-B cells, arrested B cell differentiation, arrested T cell differentiation, decreased B cell proliferation, decreased B-1a cell number, decreased B-1b cell number, decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased DN1 thymic pro-T cell number, decreased DN2 thymocyte number, decreased DN3 thymocyte number, decreased IgG3 level, decreased body size, decreased bone marrow cell number, decreased double-negative T cell number, decreased double-positive T cell number, decreased erythrocyte cell number, decreased fetal derived definitive erythrocyte cell number, decreased gamma-delta intraepithelial T cell number, decreased granulocyte number, decreased hematocrit, decreased hemoglobin content, decreased immature B cell number, decreased mature B cell number, decreased mature gamma-delta T cell number, decreased plasmacytoid dendritic cell number, decreased pre-B cell number, decreased pre-pro B cell number, decreased single-positive T cell number, decreased spleen germinal center number, decreased spleen red pulp amount, decreased splenocyte number, decreased thymocyte number, enhanced humoral immune response, enlarged cervical lymph nodes, enlarged lymph nodes, enlarged mesenteric lymph nodes, enlarged thymus, immune system phenotype, increased B-1 B cell number, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased T cell derived lymphoma incidence, increased T cell proliferation, increased central memory CD4-positive, alpha-beta T cell number, increased central memory CD8 positive, alpha-beta T cell number, increased early pro-B cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased gamma-delta T cell number, increased lymphoma incidence, increased macrophage cell number, increased nucleated erythrocyte cell number, increased pre-B cell number, increased pro-B cell number, increased response to antigen, increased single-positive T cell number, increased spleen white pulp amount, intermingled spleen red and white pulp, lethality throughout fetal growth and development, complete penetrance, lethality, complete penetrance, liver hypoplasia, multifocal hepatic necrosis, myeloid hyperplasia, postnatal lethality, incomplete penetrance, premature death, spleen hyperplasia, thymus cortex hypoplasia