nkx2-3 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-852995

Gene Symbol: nkx2-3 Gene Name: NK2 homeobox 3

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: nkx2-3 assayed (12 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (41 sources): abnormal Peyer's patch follicle morphology, abnormal cell proliferation, abnormal crypts of Lieberkuhn morphology, abnormal duodenum morphology, abnormal gut-associated lymphoid tissue morphology, abnormal intestinal epithelium morphology, abnormal intestinal mucosa morphology, abnormal intestinal peristalsis, abnormal jejunum crypts of Lieberkuhn morphology, abnormal jejunum morphology, abnormal leukocyte migration, abnormal marginal zone B cell morphology, abnormal mesenteric lymph node morphology, abnormal metallophilic macrophage morphology, abnormal molar cusp morphology, abnormal oropharynx morphology, abnormal spleen B cell follicle morphology, abnormal spleen marginal sinus morphology, abnormal spleen marginal zone macrophage morphology, abnormal spleen periarteriolar lymphoid sheath morphology, abnormal spleen primary B follicle morphology, abnormal spleen red pulp morphology, abnormal splenic cell ratio, abnormal sublingual gland morphology, abnormal tooth development, absent marginal zone B cells, absent spleen marginal zone, decreased CD4-positive, alpha beta T cell number, decreased Peyer's patch number, decreased molar number, decreased plasma cell number, decreased spleen weight, decreased spleen white pulp amount, delayed intestine development, increased enterocyte cell number, intermingled spleen red and white pulp, postnatal lethality, incomplete penetrance, small Peyer's patches, small cecum, small spleen, spleen atrophy [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (41 sources): abnormal Peyer's patch follicle morphology, abnormal cell proliferation, abnormal crypts of Lieberkuhn morphology, abnormal duodenum morphology, abnormal gut-associated lymphoid tissue morphology, abnormal intestinal epithelium morphology, abnormal intestinal mucosa morphology, abnormal intestinal peristalsis, abnormal jejunum crypts of Lieberkuhn morphology, abnormal jejunum morphology, [+]