|
XB-GENEPAGE-852756
kmt5b lysine methyltransferase 5B
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
|
|---|
| abnormal multiciliated cell morphology (8 sources), abnormal embryo morphology (6 sources), abnormally decreased number of cilium in the ciliated cell (6 sources), decreased length of tail (4 sources), abnormal ciliary axoneme morphology (1 source), abnormal cilium motility (1 source), abnormal development of basal body (1 source), abnormal development of embryo (1 source), abnormal histone methylation (1 source), abnormal main body axis morphology (1 source), abnormal multiciliated cell (1 source), abnormal ventral trunk morphology (1 source), absent swimming behavior (1 source), decreased length of anterior-posterior axis (1 source) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
|
|---|
| Manual annotations: kmt5b manipulated (4 sources) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
|
|---|
| Xla Wt + kmt5c MO + kmt5b MO (H1/H2 double KD) (9 sources), Xtr Wt + kmt5b MO (suv4-20h1 NF4) (2 sources), Xtr Wt + kmt5b MO + kmt5c MO (H1/H2KD) (1 source), Xtr Wt + suv420h1 MO (1 source) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
|
|---|
| Human (8 sources): Abnormal foot morphology, Autistic behavior, Behavioral abnormality, Cryptorchidism, Delayed speech and language development, Febrile seizure (within the age range of 3 months to 6 years), Global developmental delay, Intellectual disability |
| Mouse (10 sources): abnormal pulmonary alveolus morphology, decreased body length, decreased body size, decreased circulating alanine transaminase level, decreased lumbar vertebrae number, increased sacral vertebrae number, increased thermal nociceptive threshold, neonatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, preweaning lethality, incomplete penetrance |
|
View all ortholog results at Monarch |