lbx1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-6457163

Gene Symbol: lbx1 Gene Name: ladybird homeobox 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased size of the myotome (3 sources), decreased size of the hypaxial muscle (2 sources), increased cell population proliferation in somite (2 sources), increased size of the hypaxial muscle (2 sources), increased size of the trunk somite (2 sources), abnormally wholly dorsalized epaxial muscle (1 source), abnormally wholly dorsalized trunk somite (1 source), absent hypaxial muscle (1 source), absent pronephric tubule (1 source), decreased cell population proliferation in myotome (1 source), decreased cell population proliferation in somite (1 source), decreased size of the epaxial muscle (1 source), decreased size of the head (1 source), decreased size of the myotome (1 source), decreased size of the trunk somite (1 source), increased cell population proliferation in myotome (1 source), increased size of the tail somite (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

increased size of the myotome (3 sources), decreased size of the hypaxial muscle (2 sources), increased cell population proliferation in somite (2 sources), increased size of the hypaxial muscle (2 sources), increased size of the trunk somite (2 sources), abnormally wholly dorsalized epaxial muscle (1 source), abnormally wholly dorsalized trunk somite (1 source), absent hypaxial muscle (1 source), absent pronephric tubule (1 source), decreased cell population proliferation in myotome (1 source), decreased cell population proliferation in somite (1 source), decreased size of the epaxial muscle (1 source), decreased size of the head (1 source), decreased size of the myotome (1 source), decreased size of the trunk somite (1 source), increased cell population proliferation in myotome (1 source), increased size of the tail somite (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: lbx1 manipulated (9 sources)
Computed annotations: lbx1 assayed (3 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + lbx1 MO (8 sources), Xla Wt + Dre.lbx1 (7 sources), Xla Wt + Dre.lbx1 + myod1 (4 sources), Xla Wt + Dre.lbx1 + myf5 (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (27 sources): abnormal GABAergic neuron morphology, abnormal coronary vessel morphology, abnormal dorsal spinal root morphology, abnormal forelimb morphology, abnormal glutaminergic neuron morphology, abnormal heart development, abnormal heart looping, abnormal hindlimb morphology, abnormal hypaxial muscle morphology, abnormal muscle precursor cell migration, abnormal myogenesis, abnormal skeletal muscle morphology, abnormal spinal cord dorsal horn morphology, absent hypaxial muscle, decreased body size, decreased skeletal muscle mass, embryonic growth arrest, embryonic lethality during organogenesis, incomplete penetrance, forelimb paralysis, hindlimb paralysis, muscle phenotype, neonatal lethality, complete penetrance, nervous system phenotype, no abnormal phenotype detected, perinatal lethality, complete penetrance, thick interventricular septum, thick ventricular wall [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (27 sources): abnormal GABAergic neuron morphology, abnormal coronary vessel morphology, abnormal dorsal spinal root morphology, abnormal forelimb morphology, abnormal glutaminergic neuron morphology, abnormal heart development, abnormal heart looping, abnormal hindlimb morphology, abnormal hypaxial muscle morphology, abnormal muscle precursor cell migration, [+]