il4 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (11)

XB-GENEPAGE-6453429

Gene Symbol: il4 Gene Name: interleukin 4

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (72 sources): CNS inflammation, abnormal T cell activation, abnormal T cell differentiation, abnormal T-helper 1 cell differentiation, abnormal T-helper 2 cell differentiation, abnormal T-helper 2 physiology, abnormal dendritic cell antigen presentation, abnormal dendritic cell differentiation, abnormal humoral immune response, abnormal interleukin-4 secretion, abnormal intestinal goblet cell morphology, abnormal mammary gland growth during pregnancy, abnormal microglial cell morphology, abnormal osteoblast physiology, abnormal osteoclast physiology, abnormal physiological response to xenobiotic, abnormal response to infection, abnormal salivary gland physiology, abnormal splenocyte physiology, abnormal susceptibility to infection, abnormal thymocyte activation, abnormal thymus cell ratio, abnormal thymus morphology, acanthosis, autoimmune response, cellular phenotype, decreased CD4-positive, alpha beta T cell number, decreased IgG1 level, decreased IgG2a level, decreased airway responsiveness, decreased bone strength, decreased double-positive T cell number, decreased eosinophil cell number, decreased interferon-gamma secretion, decreased interleukin-10 secretion, decreased interleukin-13 secretion, decreased interleukin-3 secretion, decreased interleukin-4 secretion, decreased interleukin-5 secretion, decreased susceptibility to autoimmune disorder, decreased susceptibility to injury, decreased susceptibility to parasitic infection, decreased trabecular bone mass, dermatitis, epidermal spongiosis, excessive scratching, granulomatous inflammation, ileum inflammation, immune system phenotype, impaired eosinophil recruitment, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased IgG1 level, increased IgG2a level, increased IgG2c level, increased circulating glucose level, increased diameter of femur, increased double-negative T cell number, increased interferon-gamma secretion, increased interleukin-13 secretion, increased interleukin-4 secretion, increased interleukin-5 secretion, increased mast cell degranulation, increased pruritus, increased susceptibility to autoimmune disorder, increased susceptibility to parasitic infection, increased susceptibility to parasitic infection induced morbidity/mortality, insulitis, lacrimal gland inflammation, no abnormal phenotype detected, salivary gland inflammation, thymus cortex hypoplasia [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (72 sources): CNS inflammation, abnormal T cell activation, abnormal T cell differentiation, abnormal T-helper 1 cell differentiation, abnormal T-helper 2 cell differentiation, abnormal T-helper 2 physiology, abnormal dendritic cell antigen presentation, abnormal dendritic cell differentiation, abnormal humoral immune response, abnormal interleukin-4 secretion, [+]