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Summary Expression Phenotypes Gene Literature (57) GO Terms (8) Nucleotides (244) Proteins (63) Interactants (429) Wiki

raf1     Raf-1 proto-oncogene, serine/threonine kinase

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal main body axis (2 sources), abnormal mesoderm (2 sources), abnormal protein phosphorylation (2 sources), decreased length of trunk (2 sources), decreased size of the mesoderm (2 sources), duplicated tail (2 sources), abnormal caudal presomitic mesoderm morphology (1 source), abnormal spinal cord morphology (1 source), abnormal tail bud morphology (1 source), increased size of the mesoderm (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: raf1 manipulated (5 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + Hsa.RAF1 (3 sources), Xla Wt + Hsa.RAF1L603P LoF (2 sources), Xla Wt + Hsa.RAF1S257L GoF (1 source), Xla Wt + Hsa.RAF1T543M (1 source), Xla Wt + raf1 (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (117 sources): Abnormal bleeding, Abnormal cardiovascular system morphology, Abnormal dermatoglyphics, Abnormal endocardium morphology, Abnormal facial shape, Abnormal hair quantity, Abnormal localization of kidney, Abnormal mitral valve morphology, Abnormal platelet function, Abnormal pulmonary valve morphology, [+]
Mouse (80 sources): abnormal apoptosis, abnormal common myeloid progenitor cell morphology, abnormal dermal layer morphology, abnormal epidermis stratum corneum morphology, abnormal heart left ventricle pressure, abnormal hepatocyte morphology, abnormal liver sinusoid morphology, abnormal placenta development, abnormal placenta labyrinth morphology, abnormal placenta morphology, [+]

View all ortholog results at Monarch