tbxt.2 Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (71)

Nucleotides (119)

Interactants (497)

XB-GENEPAGE-5981735

Gene Symbol: tbxt.2 Gene Name: T, brachyury homolog, gene 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased length of anterior-posterior axis (2 sources), abnormal dorsal fin morphology (1 source), abnormal gastrulation (1 source), abnormal head morphology (1 source), abnormal tail morphology (1 source), abnormally delayed closure of blastopore (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: tbxt.2 manipulated (6 sources), tbxt.2 assayed (39 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + tbxt.2 MO (3 sources), Xtr Wt + vegt MO + eomes MO + tbxt MO + tbxt.2 MO (3 sources), Xtr.Wt + tbxt MO + tbxt.2 MO (2 sources), Xtr Wt + tbxt MO + tbxt.2 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (2 sources): Abnormal vertebral morphology, Absence of the sacrum
Mouse (80 sources): abnormal allantois morphology, abnormal axial mesoderm morphology, abnormal cervical atlas morphology, abnormal cervical vertebrae morphology, abnormal dorsal aorta morphology, abnormal embryo development, abnormal forelimb bud morphology, abnormal heart development, abnormal heart looping, abnormal heart tube morphology, abnormal limb bud morphology, abnormal mesoderm development, abnormal nervous system development, abnormal neural fold formation, abnormal notochord morphology, abnormal nucleus pulposus morphology, abnormal odontoid process morphology, abnormal pericardial cavity morphology, abnormal placenta development, abnormal posterior primitive streak morphology, abnormal prechordal plate morphology, abnormal primitive streak formation, abnormal rostral-caudal axis patterning, abnormal sacral vertebrae morphology, abnormal somite development, abnormal tail bud morphology, abnormal tail development, abnormal tail morphology, abnormal vertebral arch development, abnormal vertebral body morphology, absent allantois, absent anus, absent forelimb buds, absent hindlimb buds, absent notochord, absent primitive node, absent somites, absent tail, absent tail bud, absent vertebral body, bleb, caudal body truncation, curly tail, decreased body size, decreased caudal vertebrae number, decreased embryo size, decreased litter size, decreased presacral vertebrae number, decreased ventral ectodermal ridge size, delayed heart development, distended pericardium, embryonic growth arrest, embryonic growth retardation, embryonic lethality, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality between somite formation and embryo turning, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, embryonic lethality, complete penetrance, failure of heart looping, fusion of vertebral arches, incomplete caudal neuropore closure, incomplete embryo turning, incomplete somite formation, kinked neural tube, kinked tail, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, notochord degeneration, open neural tube, perinatal lethality, incomplete penetrance, postnatal lethality, prenatal lethality, prenatal lethality, complete penetrance, preweaning lethality, incomplete penetrance, reduced male fertility, short tail, split notochord, thin tail, vestigial tail [+]
View all ortholog results at Monarch