thra Phenotypes

Summary

Expression

Phenotypes

Gene Literature (137)

XB-GENEPAGE-5966550

Gene Symbol: thra Gene Name: thyroid hormone receptor alpha

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormally peramorphic growth of hindlimb bud (4 sources), increased size of the hindlimb bud (4 sources), abnormal hindlimb bud (2 sources), delayed metamorphosis (2 sources), increased thickness of the epidermis (2 sources), increased width of hindlimb bud (2 sources), abnormal iridophore (1 source), abnormal regulation of growth rate (1 source), abnormal thyroid hormone metabolic process (1 source), decreased apoptosis in tail (1 source), decreased apoptosis in tail somite (1 source), decreased length of hindlimb (1 source), decreased width of the head (1 source), increased apoptosis in tail somite (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormally peramorphic growth of hindlimb bud (4 sources), increased size of the hindlimb bud (4 sources), abnormal hindlimb bud (2 sources), delayed metamorphosis (2 sources), increased thickness of the epidermis (2 sources), increased width of hindlimb bud (2 sources), abnormal iridophore (1 source), abnormal regulation of growth rate (1 source), abnormal thyroid hormone metabolic process (1 source), decreased apoptosis in tail (1 source), decreased apoptosis in tail somite (1 source), decreased length of hindlimb (1 source), decreased width of the head (1 source), increased apoptosis in tail somite (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: thra manipulated (1 source), thra assayed (2 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + thra TALEN (5 sources), Xtr wt + thra TALEN + mCherry (3 sources), Xla wt + Tg(thradn) + GFP (2 sources), Xla Wt + Tg(thradn) (1 source), Xtr Wt + TALEN thra (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (19 sources): Anemia, Broad-based gait, Congenital hip dislocation, Congenital hypothyroidism, Constipation, Delayed eruption of teeth, Delayed skeletal maturation, Drowsiness, Dry skin, Growth delay, Hoarse voice, Hypertelorism, Increased T3/T4 ratio, Increased body mass index, Increased body weight, Macroglossia, Omphalocele, Relative macrocephaly, Wormian bones [+]
Mouse (118 sources): abnormal Purkinje cell dendrite morphology, abnormal adipose tissue amount, abnormal bone mineral content, abnormal bone mineralization, abnormal bone remodeling, abnormal bone strength, abnormal cerebellum external granule cell layer morphology, abnormal chondrocyte physiology, abnormal cochlear outer hair cell morphology, abnormal contextual conditioning behavior, abnormal defecation, abnormal embryo size, abnormal enterocyte morphology, abnormal enterocyte physiology, abnormal enterocyte proliferation, abnormal heart rate, abnormal hormone level, abnormal insulin secretion, abnormal intestinal goblet cell morphology, abnormal intestinal mucosa morphology, abnormal lean body mass, abnormal locomotor activation, abnormal locomotor behavior, abnormal locomotor coordination, abnormal long bone diaphysis morphology, abnormal long bone epiphyseal ossification zone morphology, abnormal long bone epiphyseal plate morphology, abnormal long bone epiphyseal plate proliferative zone, abnormal long bone metaphysis morphology, abnormal mitochondrial ATP synthesis coupled electron transport, abnormal object recognition memory, abnormal osteoclast physiology, abnormal pancreatic islet morphology, abnormal postnatal growth, abnormal pup retrieval, abnormal response/metabolism to endogenous compounds, abnormal retina inner nuclear layer morphology, abnormal tail movements, abnormal thyroid follicle morphology, abnormal thyroid-stimulating hormone level, abnormal total retina thickness, behavior/neurological phenotype, decreased areal bone mineral density, decreased body length, decreased bone mineral content, decreased cardiac cell glucose uptake, decreased circulating insulin-like growth factor I level, decreased circulating thyroxine level, decreased compact bone area, decreased core body temperature, decreased exploration in new environment, decreased food intake, decreased hemoglobin content, decreased litter size, decreased liver weight, decreased mean corpuscular hemoglobin, decreased mean systemic arterial blood pressure, decreased osteoclast cell number, decreased small intestinal villus height, decreased small intestine length, decreased spleen weight, decreased startle reflex, decreased total retina thickness, decreased trabecular bone thickness, decreased ventricle muscle contractility, decreased width of hypertrophic chondrocyte zone, delayed bone ossification, delayed cranial suture closure, delayed endochondral bone ossification, delayed eyelid opening, delayed hair appearance, delayed intramembranous bone ossification, disproportionate dwarf, hearing/vestibular/ear phenotype, homeostasis/metabolism phenotype, impaired adaptive thermogenesis, impaired lipolysis, improved glucose tolerance, increased anxiety-related response, increased body temperature, increased bone mass, increased bone mineral content, increased bone trabecula number, increased circulating alkaline phosphatase level, increased circulating glucose level, increased circulating thyroid-stimulating hormone level, increased compact bone thickness, increased compact bone volume, increased diameter of long bones, increased epididymal fat pad weight, increased glucagon secretion, increased insulin secretion, increased insulin sensitivity, increased lean body mass, increased long bone epiphyseal plate size, increased startle reflex, increased thyroid-stimulating hormone level, increased total body fat amount, increased trabecular bone thickness, increased trabecular bone volume, increased triiodothyronine level, limb grasping, osteosclerosis, perinatal lethality, incomplete penetrance, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, premature death, prenatal lethality, complete penetrance, preweaning lethality, incomplete penetrance, prolonged QRS complex duration, prolonged estrous cycle, reduced female fertility, reduced fertility, reduced male fertility, short tail, skeleton phenotype, small heart, small pancreatic islets [+]
View all ortholog results at Monarch