| Monarch Ortholog Phenotypes
|
Human (23 sources):
Abnormal pulmonary interstitial morphology,
Anemia,
Arthralgia,
Cutis marmorata,
Elevated erythrocyte sedimentation rate,
Erythema,
Failure to thrive,
Fever,
Follicular hyperplasia,
Growth delay,
Increased circulating antibody level,
Joint stiffness,
Leukopenia,
Malar rash,
Myalgia,
Myositis,
Nail dystrophy,
Pustule,
Raynaud phenomenon,
Recurrent infections,
Recurrent respiratory infections,
Telangiectasia,
Thrombocytosis
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Mouse (28 sources):
abnormal cytokine level,
abnormal dendritic cell physiology,
abnormal enterocyte apoptosis,
abnormal humoral immune response,
abnormal immune cell physiology,
abnormal innate immunity,
abnormal lung thrombosis,
abnormal macrophage physiology,
abnormal plasmacytoid dendritic cell physiology,
abnormal response to infection,
abnormal susceptibility to Herpesvirales infection,
decreased circulating interferon-alpha level,
decreased circulating interferon-beta level,
decreased circulating interleukin-6 level,
decreased single-positive T cell number,
hematopoietic system phenotype,
immune system phenotype,
increased circulating interleukin-10 level,
increased circulating interleukin-13 level,
increased circulating tumor necrosis factor level,
increased myeloid cell number,
increased susceptibility to Herpesvirales infection,
increased susceptibility to Herpesvirales infection induced morbidity/mortality,
increased susceptibility to Retroviridae infection,
increased susceptibility to Riboviria infection,
prenatal lethality, complete penetrance,
renal/urinary system phenotype,
skin lesions
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.