Palmoplantar keratoderma, Sensorineural hearing impairment

abnormal heart position or orientation, abnormal impulse conducting system conduction, abnormal intercalated disk morphology, abnormal mesoderm development, abnormal myocardial fiber morphology, abnormal neural fold formation, abnormal pericardial cavity morphology, abnormal spinal nerve morphology, absent atrioventricular cushions, absent brain ventricles, absent heart valves, cardiac fibrosis, cardiac hypertrophy, decreased brain size, decreased cardiac muscle contractility, decreased embryo size, decreased embryonic neuroepithelium thickness, decreased myocardial fiber number, decreased somite size, decreased ventricle muscle contractility, delayed heart development, dilated heart left ventricle, dilated vasculature, embryonic growth arrest, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, failure of somite differentiation, incomplete rostral neuropore closure, increased apoptosis, increased embryonic neuroepithelium apoptosis, increased fibroblast proliferation, increased heart weight, increased sensitivity to induced morbidity/mortality, premature death, prolonged QRS complex duration, short rostral-caudal axis, small brain ventricles, small dorsal root ganglion, small forelimb buds, small heart, thin myocardium, wavy neural tube