| Monarch Ortholog Phenotypes
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Human (47 sources):
Abnormal cardiovascular system morphology,
Abnormal morphology of female internal genitalia,
Abnormality of the voice,
Anosmia,
Anterior hypopituitarism,
Ataxia,
Bimanual synkinesia,
Breast hypoplasia,
Cleft palate,
Color vision defect,
Cryptorchidism,
Decreased fertility,
Decreased testicular size,
Delayed puberty,
Delayed skeletal maturation,
Dysarthria,
Dyspareunia,
Erectile dysfunction,
Gait disturbance,
Gynecomastia,
Hearing impairment,
Hypogonadotropic hypogonadism,
Hypoplasia of penis,
Hyposmia,
Hypothalamic gonadotropin-releasing hormone deficiency,
Hypotonia,
Ichthyosis,
Micropenis,
Muscle weakness,
Nystagmus,
Obesity,
Osteopenia,
Osteoporosis,
Paraplegia,
Pes cavus,
Pes planus,
Primary amenorrhea,
Ptosis,
Recurrent fractures,
Reduced bone mineral density,
Renal agenesis,
Seizure,
Sensorineural hearing impairment,
Skeletal dysplasia,
Tooth agenesis,
Tremor,
Visual impairment
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Mouse (18 sources):
abnormal anterior visceral endoderm morphology,
abnormal basement membrane morphology,
abnormal embryo development,
abnormal embryonic neuroepithelium morphology,
abnormal embryonic tissue morphology,
abnormal endoderm development,
abnormal heart development,
cardia bifida,
disorganized embryonic tissue,
embryonic growth retardation,
embryonic lethality during organogenesis, incomplete penetrance,
failure of initiation of embryo turning,
failure of ventral body wall closure,
impaired basement membrane formation,
incomplete rostral neuropore closure,
postnatal lethality, incomplete penetrance,
preweaning lethality, incomplete penetrance,
rostral body truncation
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.