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Summary Expression Phenotypes Gene Literature (456) GO Terms (15) Nucleotides (103) Proteins (33) Interactants (2052) Wiki

shh     sonic hedgehog

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal intestine morphology (3 sources), abnormal bending of tail (2 sources), abnormal regenerating forelimb morphology (2 sources), abnormally decreased number of melanophore (2 sources), abnormally localised eye (2 sources), decreased size of the intercanthal region (2 sources), edematous ventral trunk (2 sources), abnormal development of alimentary system (1 source), abnormal digit-joint region (1 source), abnormal digit-joint region morphology in the regenerating forelimb (1 source), abnormal forelimb digit (1 source), abnormal regenerating forelimb (1 source), abnormal spike (1 source), abnormally decreased number of digit-joint region in the regenerating forelimb (1 source), abnormally increased number of melanophore (1 source), abnormally wholly ventralized eye (1 source), increased branchiness of regenerating forelimb (1 source), increased size of the regenerating forelimb (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: shh manipulated (10 sources), shh assayed (15 sources)
Computed annotations: shh assayed (10 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + shh (7 sources), Xla Wt + shh MO (5 sources), Xla Wt + shh MO (3 sources), Xla Wt + shh MO (3 sources), Xla Wt + Hsa.FGF10 + Hsa.SHH + TMSB4X + forelimb amputation (2 sources), Xla Wt + Hsa.FGF10 + Hsa.SHH + forelimb amputation (1 source), Xla Wt + Hsa.SHH + animal cap explant (1 source), Xla Wt + Hsa.SHH + forelimb amputation (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (111 sources): 1-5 finger complete cutaneous syndactyly, 1-5 finger syndactyly, 2-3 toe syndactyly, 6 metacarpals, Abnormal cardiovascular system morphology, Abnormal nasopharynx morphology, Abnormal thumb morphology, Abnormality of chromosome segregation, Abnormality of fibula morphology, Abnormality of the nose, [+]
Mouse (218 sources): abnormal adrenocortical cell morphology, abnormal ameloblast morphology, abnormal artery morphology, abnormal astrocyte morphology, abnormal atrium myocardium morphology, abnormal brain interneuron morphology, abnormal branching involved in lung morphogenesis, abnormal bronchus morphology, abnormal cardiac outflow tract development, abnormal cartilage development, [+]

View all ortholog results at Monarch