ptpn6 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-487862

Gene Symbol: ptpn6 Gene Name: protein tyrosine phosphatase non-receptor type 6

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ptpn6 assayed (1 source)
Computed annotations: ptpn6 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (94 sources): abnormal CD8-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal CNS glial cell morphology, abnormal Peyer's patch morphology, abnormal T cell differentiation, abnormal astrocyte morphology, abnormal bone marrow cell physiology, abnormal cell cycle checkpoint function, abnormal circulating chemokine level, abnormal coat appearance, abnormal hippocampus CA1 region morphology, abnormal hippocampus development, abnormal humoral immune response, abnormal lymph organ size, abnormal microglial cell morphology, abnormal photoreceptor inner segment morphology, abnormal photoreceptor outer segment morphology, abnormal plasma cell morphology, abnormal pulmonary alveolar system morphology, abnormal skin condition, abnormal telencephalon development, abnormal tertiary ovarian follicle morphology, abnormal thymus development, abnormal thymus morphology, absent limbs, autoimmune response, chronic inflammation, decreased B cell proliferation, decreased B-1 B cell number, decreased B-2 B cell number, decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased a-wave amplitude, decreased apoptosis, decreased b-wave amplitude, decreased body size, decreased bone mass, decreased bone mineral content, decreased brain size, decreased cellular sensitivity to gamma-irradiation, decreased follicular B cell number, decreased immature B cell number, decreased marginal zone B cell number, decreased mature B cell number, decreased neuron number, decreased retina photoreceptor cell number, decreased susceptibility to bacterial infection, decreased susceptibility to bacterial infection induced morbidity/mortality, decreased thymocyte number, disorganized photoreceptor outer segment, enlarged lymph nodes, extremity edema, focal hair loss, increased B-1 B cell number, increased B-1a cell number, increased B-1b cell number, increased CD8-positive, alpha-beta memory T cell number, increased anti-chromatin antibody level, increased autoantibody level, increased central memory CD8 positive, alpha-beta T cell number, increased circulating interferon-gamma level, increased circulating interleukin-1 beta level, increased circulating interleukin-10 level, increased circulating interleukin-17 level, increased circulating interleukin-6 level, increased circulating serum amyloid protein level, increased dendritic cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased granulocyte number, increased macrophage cell number, increased microglial cell activation, increased neutrophil cell number, increased plasma cell number, increased splenocyte proliferation, increased susceptibility to systemic lupus erythematosus, integument phenotype, ovary atrophy, postnatal lethality, postnatal lethality, complete penetrance, premature death, preweaning lethality, incomplete penetrance, reproductive system phenotype, retina outer nuclear layer degeneration, retina photoreceptor degeneration, retina rod cell degeneration, salivary gland inflammation, short photoreceptor outer segment, skin lesions, small thymus, thin retina outer nuclear layer, thymus atrophy, ulcerated paws, vision/eye phenotype [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (94 sources): abnormal CD8-positive, alpha beta T cell morphology, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal CNS glial cell morphology, abnormal Peyer's patch morphology, abnormal T cell differentiation, abnormal astrocyte morphology, abnormal bone marrow cell physiology, abnormal cell cycle checkpoint function, abnormal circulating chemokine level, abnormal coat appearance, [+]