nog Phenotypes

Summary

Expression

Phenotypes

Gene Literature (538)

XB-GENEPAGE-487723

Gene Symbol: nog Gene Name: noggin

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
partially dorsalized embryo (5 sources), wholly dorsalized embryo (2 sources), wholly ventralized embryo (2 sources), abnormal axis specification (1 source), abnormal development of head (1 source), abnormal gastrulation (1 source), abnormal head morphology (1 source), abnormally decreased number of bipolar neuron in the retinal inner plexiform layer (1 source), abnormally posterioralized embryo (1 source), abnormally ventralized embryo (1 source), increased size of the cement gland (1 source), increased size of the eye (1 source), obsolete duplicated anterior-posterior axis (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

partially dorsalized embryo (5 sources), wholly dorsalized embryo (2 sources), wholly ventralized embryo (2 sources), abnormal axis specification (1 source), abnormal development of head (1 source), abnormal gastrulation (1 source), abnormal head morphology (1 source), abnormally decreased number of bipolar neuron in the retinal inner plexiform layer (1 source), abnormally posterioralized embryo (1 source), abnormally ventralized embryo (1 source), increased size of the cement gland (1 source), increased size of the eye (1 source), obsolete duplicated anterior-posterior axis (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: nog manipulated (12 sources), nog assayed (3 sources)
Computed annotations: nog manipulated (4 sources), nog assayed (32 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + nog (5 sources), Xla Wt + Hsa.NOG (3 sources), Xtr Wt + nog CRISPR (2 sources), Xtr Wt + rspo2 CRISPR + nog CRISPR (2 sources), Xla Wt + chrd MO + nog MO (1 source), Xla Wt + chrd MO + nog MO (1 source), Xla Wt + Hsa.SHOX-nog (1 source), Xla Wt + Hsa.SHOXdel-nog (1 source), Xla Wt + Hsa.SHOXdel-nog (1 source), Xla Wt + Hsa.SHOXtm-nog (1 source), Xla Wt + Hsa.SHOXtm-nog (1 source), Xla Wt + nog (1 source), Xla Wt + nog (1 source), Xla Wt + nog (1 source), Xla Wt + nog + epha4 MO + animal cap explant (1 source), Xla Wt + nog + sipa1l3 MO + animal cap explant (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + animal cap explant (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + CHX + animal cap explant (1 source), Xla Wt + nog - animal cap explant (1 source), Xla Wt + vegt + nog + cyp26a1 + CHX + animal cap explant (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + nog (5 sources), Xla Wt + Hsa.NOG (3 sources), Xtr Wt + nog CRISPR (2 sources), Xtr Wt + rspo2 CRISPR + nog CRISPR (2 sources), Xla Wt + chrd MO + nog MO (1 source), Xla Wt + chrd MO + nog MO (1 source), Xla Wt + Hsa.SHOX-nog (1 source), Xla Wt + Hsa.SHOXdel-nog (1 source), Xla Wt + Hsa.SHOXdel-nog (1 source), Xla Wt + Hsa.SHOXtm-nog (1 source), Xla Wt + Hsa.SHOXtm-nog (1 source), Xla Wt + nog (1 source), Xla Wt + nog (1 source), Xla Wt + nog (1 source), Xla Wt + nog + epha4 MO + animal cap explant (1 source), Xla Wt + nog + sipa1l3 MO + animal cap explant (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + animal cap explant (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + CHX + animal cap explant (1 source), Xla Wt + nog - animal cap explant (1 source), Xla Wt + vegt + nog + cyp26a1 + CHX + animal cap explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (88 sources): 2-3 toe syndactyly, Abnormal vertebral morphology, Abnormality of the ankles, Abnormality of the metacarpal bones, Abnormality of the nail, Abnormality of the wrist, Absent distal interphalangeal creases, Absent distal phalanges, Absent fingernail, Absent phalangeal crease, Anonychia, Aplasia/Hypoplasia of the distal phalanges of the hand, Aplasia/Hypoplasia of the distal phalanges of the toes, Aplasia/Hypoplasia of the middle phalanges of the hand, Aplasia/Hypoplasia of the middle phalanges of the toes, Aplasia/Hypoplasia of the nails, Aplastic/hypoplastic toenail, Bilateral single transverse palmar creases, Brachydactyly, Broad hallux, Broad thumb, Camptodactyly of finger, Carpal synostosis, Clinodactyly, Clinodactyly of the 5th finger, Conductive hearing impairment, Cone-shaped epiphysis, Congenital stapes ankylosis, Cubitus valgus, Cutaneous finger syndactyly, Cutaneous syndactyly of toes, Dislocated radial head, Distal symphalangism of hands, Elbow ankylosis, Elbow dislocation, Enlargement of the costochondral junction, Facial asymmetry, Finger clinodactyly, Finger syndactyly, Fused cervical vertebrae, Humeroradial synostosis, Hypermetropia, Hypoplastic nasal septum, Hypoplastic spinal processes, Joint stiffness, Limited neck range of motion, Long nose, Low hanging columella, Lower limb undergrowth, Metacarpophalangeal synostosis, Narrow face, Pectus excavatum, Progressive conductive hearing impairment, Progressive fusion 2nd-5th pip joints, Proximal placement of thumb, Proximal symphalangism, Proximal symphalangism of hands, Proximal/middle symphalangism of 5th finger, Radial deviation of finger, Sensorineural hearing impairment, Short 1st metacarpal, Short 5th metacarpal, Short distal phalanx of finger, Short distal phalanx of toe, Short finger, Short foot, Short hallux, Short humerus, Short lower limbs, Short palm, Short philtrum, Short stature, Short sternum, Short toe, Single transverse palmar crease, Spinal canal stenosis, Stapes ankylosis, Strabismus, Symphalangism affecting the phalanges of the hand, Synostosis of carpal bones, Tarsal synostosis, Thick upper lip vermilion, Thin upper lip vermilion, Toe syndactyly, Type B brachydactyly, Underdeveloped nasal alae, Waddling gait, obsolete Fusion of midphalangeal joints [+]
Mouse (78 sources): abnormal Rathke's pouch apoptosis, abnormal Rathke's pouch development, abnormal apical ectodermal ridge morphology, abnormal basicranium morphology, abnormal bone mineralization, abnormal cartilage development, abnormal cochlea morphology, abnormal craniofacial morphology, abnormal diencephalon morphology, abnormal ear development, abnormal esophagus development, abnormal eye development, abnormal foregut morphology, abnormal frontal bone morphology, abnormal hair follicle development, abnormal incus morphology, abnormal interdigital cell death, abnormal interparietal bone morphology, abnormal limb bud morphology, abnormal limb morphology, abnormal lung development, abnormal malleus morphology, abnormal mandible morphology, abnormal middle ear ossicle morphology, abnormal muscle fiber morphology, abnormal neural plate morphology, abnormal notochord morphology, abnormal occipital bone morphology, abnormal pituitary gland development, abnormal pituitary gland physiology, abnormal placenta morphology, abnormal placenta vasculature, abnormal primitive urogenital sinus morphology, abnormal prostate gland development, abnormal prostate gland morphology, abnormal right lung morphology, abnormal rostral-caudal patterning of the somites, abnormal septation of the cloaca, abnormal skeleton development, abnormal snout morphology, abnormal somite development, abnormal styloid process morphology, abnormal urinary system development, abnormal vertebral arch morphology, abnormal vibrissa morphology, absent Rathke's pouch, absent adenohypophysis, absent bulbourethral gland, absent pituitary infundibular stalk, absent tail, absent vertebral arch, conductive hearing loss, decreased embryo size, decreased fetal size, decreased somite size, fused synovial joints, hearing/vestibular/ear phenotype, hematoma, incomplete rostral neuropore closure, increased apoptosis, increased cochlear inner hair cell number, increased cochlear outer hair cell number, increased heart weight, increased or absent threshold for auditory brainstem response, interdigital webbing, kinked neural tube, kinked tail, lethality throughout fetal growth and development, complete penetrance, open neural tube, perinatal lethality, complete penetrance, polysyndactyly, preweaning lethality, complete penetrance, slow postnatal weight gain, small limb buds, small prostate gland ventral lobe, small thoracic cage, vestigial tail, wavy neural tube [+]
View all ortholog results at Monarch