hhex Phenotypes

Summary

Expression

Phenotypes

Gene Literature (127)

XB-GENEPAGE-487158

Gene Symbol: hhex Gene Name: hematopoietically expressed homeobox

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal endoderm morphology (1 source), abnormal foregut morphology (1 source), abnormal gastrulation (1 source), absent dorsal pancreatic bud (1 source), absent ventral pancreatic bud (1 source), duplicated head (1 source), obsolete duplicated anatomical axis (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: hhex manipulated (11 sources), hhex assayed (143 sources)
Computed annotations: hhex assayed (27 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + hhex MO (5 sources), Xla Wt + hhex + ctnnb1 (4 sources), Xla Wt + hhex (3 sources), Xla Wt + hhex MO (1 source), Xtr Wt + hhex CRISPR (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (61 sources): abnormal anterior definitive endoderm morphology, abnormal anterior visceral endoderm morphology, abnormal atrioventricular cushion morphology, abnormal atrioventricular valve morphology, abnormal bile duct development, abnormal cardiac epithelial to mesenchymal transition, abnormal common myeloid progenitor cell morphology, abnormal conotruncal ridge morphology, abnormal definitive hematopoiesis, abnormal double-negative T cell morphology, abnormal egg cylinder morphology, abnormal embryo development, abnormal extrahepatic bile duct morphology, abnormal first pharyngeal arch morphology, abnormal forebrain development, abnormal hepatic diverticulum morphology, abnormal hepatic duct morphology, abnormal hepatoblast migration, abnormal hepatocyte morphology, abnormal intrahepatic bile duct morphology, abnormal liver bud morphology, abnormal liver development, abnormal medial ganglionic eminence morphology, abnormal monocyte differentiation, abnormal nasal placode morphology, abnormal optic stalk morphology, abnormal optic vesicle formation, abnormal pericardial cavity morphology, abnormal primitive streak morphology, abnormal survival, abnormal telencephalon development, abnormal thymus corticomedullary boundary morphology, abnormal thyroid gland development, abnormal vasculogenesis, absent Rathke's pouch, absent embryonic telencephalon, absent forebrain, absent liver, absent nasal placodes, conotruncal ridge hyperplasia, decreased double-positive T cell number, decreased forebrain size, decreased heart right ventricle size, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, fused first pharyngeal arch, heart right ventricle outflow tract stenosis, impaired hematopoiesis, increased CD8-positive, alpha-beta T cell number, increased atrioventricular cushion size, lethality throughout fetal growth and development, complete penetrance, liver hypoplasia, pericardial edema, prenatal lethality, complete penetrance, preweaning lethality, incomplete penetrance, rostral body truncation, small embryonic telencephalon, thin myocardium compact layer, thin ventricular wall, vascular smooth muscle hypoplasia [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (61 sources): abnormal anterior definitive endoderm morphology, abnormal anterior visceral endoderm morphology, abnormal atrioventricular cushion morphology, abnormal atrioventricular valve morphology, abnormal bile duct development, abnormal cardiac epithelial to mesenchymal transition, abnormal common myeloid progenitor cell morphology, abnormal conotruncal ridge morphology, abnormal definitive hematopoiesis, abnormal double-negative T cell morphology, [+]