xbp1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-487123

Gene Symbol: xbp1 Gene Name: X-box binding protein 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal foregut morphology (3 sources), abnormal intestine morphology (2 sources), abnormally coiled small intestine (1 source), decreased cell population proliferation in embryo (1 source), decreased pigmentation in the eye (1 source), increased apoptosis in embryo (1 source), increased apoptosis in trunk (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: xbp1 manipulated (7 sources)
Computed annotations: xbp1 assayed (13 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + xbp1 MO (8 sources), Xla Wt + xbp1 + DEX (2 sources), Xla Wt + xbp1 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (65 sources): abnormal autophagy, abnormal blood flow velocity, abnormal bone mineralization, abnormal cell migration, abnormal endoplasmic reticulum morphology, abnormal enterocyte physiology, abnormal extraembryonic tissue physiology, abnormal heart development, abnormal intestine physiology, abnormal lipid homeostasis, abnormal liver development, abnormal nucleotide metabolism, abnormal Paneth cell morphology, abnormal physiological neovascularization, abnormal red blood cell distribution width, abnormal response to injury, abnormal retina blood vessel morphology, abnormal sinus arrhythmia, abnormal small intestine goblet cell morphology, abnormal white adipose tissue morphology, absent Paneth cells, absent trabeculae carneae, anoxia, behavior/neurological phenotype, crypts of Lieberkuhn abscesses, decreased angiogenesis, decreased body fat mass, decreased brown adipose tissue mass, decreased cell proliferation, decreased cholesterol level, decreased embryo size, decreased embryo weight, decreased fat cell size, decreased fatty acids level, decreased hepatocyte proliferation, decreased IgG1 level, decreased Paneth cell number, decreased red blood cell distribution width, decreased small intestinal villus size, decreased susceptibility to diet-induced obesity, decreased susceptibility to prion infection, decreased white adipose tissue mass, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryo tissue necrosis, enlarged pericardium, impaired hematopoiesis, increased apoptosis, increased basal metabolism, increased body fat mass, increased carbon dioxide production, increased fatty acid oxidation, increased grip strength, increased hepatocyte apoptosis, increased oxygen consumption, increased susceptibility to induced colitis, increased total body fat amount, intestinal ulcer, liver hypoplasia, nervous system phenotype, preweaning lethality, complete penetrance, small intestinal inflammation, small liver, thin ventricular wall, wavy neural tube [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (65 sources): abnormal autophagy, abnormal blood flow velocity, abnormal bone mineralization, abnormal cell migration, abnormal endoplasmic reticulum morphology, abnormal enterocyte physiology, abnormal extraembryonic tissue physiology, abnormal heart development, abnormal intestine physiology, abnormal lipid homeostasis, [+]