| Monarch Ortholog Phenotypes
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Human (16 sources):
Abnormality of neutrophils,
Atrial fibrillation,
Cardiomyopathy,
Dilated cardiomyopathy,
EMG abnormality,
Elevated circulating creatine kinase concentration,
Left atrial enlargement,
Left ventricular hypertrophy,
Lipoatrophy,
Myopathy,
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Mouse (29 sources):
abnormal I band morphology,
abnormal Z line morphology,
abnormal heart echocardiography feature,
abnormal lung vasculature morphology,
abnormal myocardial fiber morphology,
abnormal myocardial fiber physiology,
abnormal myocardium layer morphology,
abnormal sarcomere morphology,
abnormal sarcoplasmic reticulum morphology,
cardiac hypertrophy,
cardiac interstitial fibrosis,
cardiovascular system phenotype,
decreased cardiac muscle contractility,
decreased cardiac muscle relaxation,
decreased heart weight,
dilated heart atrium,
impaired exercise endurance,
increased cardiac muscle contractility,
increased heart weight,
increased left ventricle diastolic pressure,
increased response of heart to induced stress,
increased systemic arterial diastolic blood pressure,
postnatal lethality,
postnatal lethality, complete penetrance,
premature death,
preweaning lethality, complete penetrance,
small heart,
thick interventricular septum,
thick ventricular wall
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.