tbx5 Phenotypes

Phenotypes

XB-GENEPAGE-486854

Gene Symbol: tbx5 Gene Name: T-box 5

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
absent blood in the heart (1 source), absent lung bud (1 source), edematous embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tbx5 manipulated (2 sources), tbx5 assayed (1 source)
Computed annotations: tbx5 assayed (2 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + tbx5 CRISPR (3 sources), Xtr Wt + tbx5 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (46 sources): Abnormal aortic morphology, Abnormal cardiovascular system morphology, Abnormal carpal morphology, Abnormal clavicle morphology, Abnormality of the humerus, Abnormal rib morphology, Abnormal vertebral morphology, Absent radius, Absent thumb, Anomalous pulmonary venous return, Aplasia/Hypoplasia of the radius, Aplasia of the pectoralis major muscle, Aplasia of the ulna, Atrial septal defect, Atrioventricular block, Atrioventricular canal defect, Brachydactyly, Broad thumb, Down-sloping shoulders, Finger clinodactyly, Finger syndactyly, First degree atrioventricular block, Hypoplasia of the radius, Hypoplasia of the ulna, Hypoplastic left heart, Joint stiffness, Kyphosis, Limited elbow extension, obsolete Abnormality of the metacarpal bones, Paroxysmal atrial fibrillation, Partial duplication of thumb phalanx, Patent ductus arteriosus, Pectus excavatum, Phocomelia, Radioulnar synostosis, Scoliosis, Secundum atrial septal defect, Short clavicles, Short humerus, Small thenar eminence, Split hand, Sprengel anomaly, Syndactyly, Thoracic scoliosis, Triphalangeal thumb, Ventricular septal defect [+]
View all ortholog results at Monarch

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Human (46 sources): Abnormal aortic morphology, Abnormal cardiovascular system morphology, Abnormal carpal morphology, Abnormal clavicle morphology, Abnormality of the humerus, Abnormal rib morphology, Abnormal vertebral morphology, Absent radius, Absent thumb, Anomalous pulmonary venous return, [+]