gsc Phenotypes

Summary

Expression

Phenotypes

Gene Literature (616)

XB-GENEPAGE-486770

Gene Symbol: gsc Gene Name: goosecoid homeobox

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal eye morphology (5 sources), absent eye (5 sources), absent head (4 sources), duplicated main body axis (4 sources), abnormal embryo morphology (3 sources), duplicated head (3 sources), abnormal head morphology (2 sources), abnormal retina morphology (2 sources), decreased length of tail (2 sources), decreased size of the eye (2 sources), fused eyes (2 sources), abnormal forebrain (1 source), abnormal foregut morphology (1 source), abnormal tail morphology (1 source), absent optic stalk (1 source), decreased size of the forebrain (1 source), decreased size of the midbrain-hindbrain boundary (1 source), duplicated eye (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal eye morphology (5 sources), absent eye (5 sources), absent head (4 sources), duplicated main body axis (4 sources), abnormal embryo morphology (3 sources), duplicated head (3 sources), abnormal head morphology (2 sources), abnormal retina morphology (2 sources), decreased length of tail (2 sources), decreased size of the eye (2 sources), fused eyes (2 sources), abnormal forebrain (1 source), abnormal foregut morphology (1 source), abnormal tail morphology (1 source), absent optic stalk (1 source), decreased size of the forebrain (1 source), decreased size of the midbrain-hindbrain boundary (1 source), duplicated eye (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: gsc manipulated (6 sources), gsc assayed (55 sources)
Computed annotations: gsc assayed (44 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + gsc MO (3 sources), Xla Wt + tle1 + gsc + otx2 + ssbp3 + ldb1 + lhx1 mRNA (3 sources), Xtr Wt + otx2 MO + crx MO + gsc MO + lhx1 MO (3 sources), Xbo Wt + gsc MO + cdx1 MO (VMZ) (1 source), Xla Wt + gsc (1 source), Xla Wt + gsc (1 source), Xla Wt + gsc MO (1 source), Xla Wt + gsc MO + cdx1 MO (DMZ) (1 source), Xla Wt + gsc + ssbp3 + tle1 + lhx1 mRNA 5 (1 source), Xla Wt + tle1 + otx2 + gsc mRNA (1 source), Xtr Wt + gsc MO (1 source), Xtr Wt + gsc MO + crx MO + otx2 MO (1 source), Xtr Wt + lhx1 MO + gsc MO (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + gsc MO (3 sources), Xla Wt + tle1 + gsc + otx2 + ssbp3 + ldb1 + lhx1 mRNA (3 sources), Xtr Wt + otx2 MO + crx MO + gsc MO + lhx1 MO (3 sources), Xbo Wt + gsc MO + cdx1 MO (VMZ) (1 source), Xla Wt + gsc (1 source), Xla Wt + gsc (1 source), Xla Wt + gsc MO (1 source), Xla Wt + gsc MO + cdx1 MO (DMZ) (1 source), Xla Wt + gsc + ssbp3 + tle1 + lhx1 mRNA 5 (1 source), Xla Wt + tle1 + otx2 + gsc mRNA (1 source), Xtr Wt + gsc MO (1 source), Xtr Wt + gsc MO + crx MO + otx2 MO (1 source), Xtr Wt + lhx1 MO + gsc MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (22 sources): Atresia of the external auditory canal, Conductive hearing impairment, Cryptorchidism, Deeply set eye, Delayed ossification of pubic rami, Dislocated radial head, Downslanted palpebral fissures, Feeding difficulties, Flexion contracture, High palate, Hip dislocation, Hypoplastic scapulae, Hypotelorism, Malar flattening, Micrognathia, Narrow mouth, Preauricular pit, Rhizomelia, Scapulohumeral synostosis, Short humerus, Short stature, Talipes equinovarus [+]
Mouse (62 sources): abnormal acetabulum morphology, abnormal alisphenoid bone morphology, abnormal basicranium morphology, abnormal breathing pattern, abnormal craniofacial morphology, abnormal epitympanic recess morphology, abnormal ethmoid bone morphology, abnormal external auditory canal morphology, abnormal extrinsic tongue muscle morphology, abnormal femur head morphology, abnormal frontal bone morphology, abnormal genioglossus muscle morphology, abnormal glenoid fossa morphology, abnormal hip joint morphology, abnormal horizontal basal cell of olfactory epithelium morphology, abnormal humerus morphology, abnormal intrinsic tongue muscle morphology, abnormal malleus morphology, abnormal mandible morphology, abnormal mandibular angle morphology, abnormal masticatory muscle morphology, abnormal maxilla morphology, abnormal Meckel's cartilage morphology, abnormal nasal capsule morphology, abnormal nasal cavity morphology, abnormal nasal septum morphology, abnormal obturator foramen morphology, abnormal palatine bone morphology, abnormal presphenoid bone morphology, abnormal pterygoid process morphology, abnormal pubic symphysis morphology, abnormal scapular coracoid process morphology, abnormal shoulder joint morphology, abnormal sternocostal joint morphology, abnormal suckling behavior, abnormal trochanter morphology, abnormal tympanic membrane morphology, abnormal vomer bone morphology, absent ethmoturbinates, absent gastric milk in neonates, absent malleus processus brevis, absent turbinates, absent tympanic membrane, absent tympanic ring, cervical vertebral transformation, decreased birth body size, decreased tympanic ring size, endocrine/exocrine gland phenotype, limbs/digits/tail phenotype, mandible hypoplasia, neonatal lethality, complete penetrance, palatine bone hypoplasia, presphenoid bone hypoplasia, short mandible, small alisphenoid bone, small cribriform plate, small ischium, small malleus manubrium, small malleus processus brevis, small mandibular coronoid process, small pterygoid bone, small vomer bone [+]
View all ortholog results at Monarch